CILK1 - ciliogenesis associated kinase 1 Gene

Also Known as ECO; ICK; MRK; LCK2; hICK; EJM10

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 22858

Summary

Eukaryotic protein kinases are Enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

CILK1 Products (1)

mRNA Protein Name
NM_001375400.1 NP_001362329.1 serine/threonine-protein kinase ICK isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10699974 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10699974 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
19185282 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10699974 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
24797473 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10699974 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10699974 GOA
Cellular Component GO Annotation Evidence References Source
located in ciliary tip IMP
IMP: Inferred from mutant phenotype
24797473 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19185282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase ICK

  • MAK-related kinase

  • iciliogenesis associated kinase 1

  • intestinal cell (MAK-like) kinase

  • intestinal cell kinase

  • laryngeal cancer kinase 2

  • serine/threonine protein kinase

CILK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CILK1 Q9UPZ9 SMYD2 Homo sapiens Q9NRG4
Pull Down
32707033
Intra
CILK1 Q9UPZ9 SMYD2 Homo sapiens Q9NRG4
TAP
27173435
Intra
CILK1 Q9UPZ9 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
Intra
CILK1 Q9UPZ9 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra
CILK1 Q9UPZ9 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
CILK1 Q9UPZ9 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra
CILK1 Q9UPZ9 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70691 CLK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS02814 CLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02815 Clk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02816 Clk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown