CILK1 - ciliogenesis associated kinase 1 Gene

Homo sapiens (human)

Also known as ECO; ICK; MRK; LCK2; hICK; EJM10

Gene ID: 22858 | Gene type: protein coding

About CILK1

Summary

Eukaryotic protein kinases are Enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

CILK1 Products(1)

mRNA	Protein	Name
NM_001375400.1	NP_001362329.1	serine/threonine-protein kinase ICK isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10699974	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10699974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	19185282	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10699974	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24797473	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10699974	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10699974	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary tip	IMP IMP: Inferred from mutant phenotype	24797473	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19185282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase ICK

MAK-related kinase	iciliogenesis associated kinase 1
intestinal cell (MAK-like) kinase	intestinal cell kinase
laryngeal cancer kinase 2	serine/threonine protein kinase

CILK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CILK1	Q9UPZ9	SMYD2	Homo sapiens	Q9NRG4	Pull Down	32707033
Intra	CILK1	Q9UPZ9	SMYD2	Homo sapiens	Q9NRG4	TAP	27173435
Intra	CILK1	Q9UPZ9	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781
Intra	CILK1	Q9UPZ9	FKBP5	Homo sapiens	Q13451	Pull Down	32707033
Intra	CILK1	Q9UPZ9	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	CILK1	Q9UPZ9	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	CILK1	Q9UPZ9	HSP90AB1	Homo sapiens	P08238	Lumier	22939624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70691	CLK1 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS02814	CLK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02815	Clk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02816	Clk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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