Fitm2 - fat storage-inducing transmembrane protein 2 Gene

Also Known as Fit2; D930001I22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228859

Summary

Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including cellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Acts upstream of or within sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Fitm2 Products (1)

mRNA Protein Name
NM_173397.4 NP_775573.1 acyl-coenzyme A diphosphatase FITM2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol binding IDA
IDA: Inferred from direct assay
22106267 MGI
enables triglyceride binding IDA
IDA: Inferred from direct assay
22106267 MGI
Biological Process GO Annotation Evidence References Source
involved in intracellular triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
18160536 MGI
involved in lipid droplet formation IDA
IDA: Inferred from direct assay
22106267 MGI
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
26504167 MGI
involved in lipid droplet organization IDA
IDA: Inferred from direct assay
18160536 MGI
involved in lipid droplet organization IMP
IMP: Inferred from mutant phenotype
20520733 MGI
involved in positive regulation of sequestering of triglyceride IDA
IDA: Inferred from direct assay
18160536 MGI
involved in regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
18160536 MGI
acts upstream of or within sequestering of triglyceride IMP
IMP: Inferred from mutant phenotype
24519944 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18160536 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acyl-coenzyme A diphosphatase FITM2

  • fat-inducing protein 2

  • fat-inducing transcript 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04953 FITM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fitm2 NCBI NCBI:128486