Clrn1 - clarin 1 Gene

Also Known as USH3; Ush3a; clarin-1; A130002D11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229320

Summary

Acts upstream of or within auditory receptor cell stereocilium organization; neuromuscular process controlling balance; and sensory perception of sound. Located in several cellular components, including basal part of cell; stereocilium; and trans-Golgi network transport vesicle. Is expressed in gut; male reproductive gland or organ; nervous system; sensory organ; and skin. Used to study Usher syndrome type 3A. Human ortholog(s) of this gene implicated in Usher syndrome type 3A and retinitis pigmentosa 61. Orthologous to human CLRN1 (clarin 1). [provided by Alliance of Genome Resources, Apr 2022]

Clrn1 Products (3)

mRNA Protein Name
NM_153384.3 NP_700433.1 clarin-1 isoform 1
NM_153385.3 NP_700434.1 clarin-1 isoform 2
NM_153386.3 NP_700435.1 clarin-1 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within auditory receptor cell development IMP
IMP: Inferred from mutant phenotype
19414487 MGI
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
19414487 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
19414487 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
19414487 MGI
Cellular Component GO Annotation Evidence References Source
located in basal part of cell IDA
IDA: Inferred from direct assay
19539019 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
19539019 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
19539019 MGI
located in trans-Golgi network transport vesicle IDA
IDA: Inferred from direct assay
19539019 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

clarin-1

  • Usher syndrome 3A homolog

  • usher syndrome type-3 protein homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-120726 BF844 / Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02836 CLRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clrn1 NCBI NCBI:7401