Pbxip1 - pre B cell leukemia transcription factor interacting protein 1 Gene

Also Known as 4732463H20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 229534

Summary

Enables transcription coactivator activity. Acts upstream of or within several processes, including extracellular matrix organization; histone H3-K56 acetylation; and positive regulation of chondrocyte proliferation. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in brain; diaphragm; gut; heart ventricle; and spinal cord ventricular layer. Orthologous to human PBXIP1 (PBX homeobox interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pbxip1 Products (1)

mRNA	Protein	Name
NM_146131.2	NP_666243.1	pre-B-cell leukemia transcription factor-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30659184	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	30659184	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	30659184	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within articular cartilage development	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within gene expression involved in extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	30659184	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	30659184	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within production of molecular mediator involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	30659184	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	30659184	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	30659184	MGI
is active in cytoplasm	IPI IPI: Inferred from physical interaction	30659184	MGI
located in nucleus	IDA IDA: Inferred from direct assay	30659184	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	30659184	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	30659184	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pre-B-cell leukemia transcription factor-interacting protein 1	hematopoietic PBX-interacting protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10110	PBXIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pbxip1	NCBI	NCBI:57326