Rap1gds1 - RAP1, GTP-GDP dissociation stimulator 1 Gene

Mus musculus

Also known as GDS1

Gene ID: 229877 | Gene type: protein coding

About Rap1gds1

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of GTPase activity; and positive regulation of mitochondrial calcium ion concentration. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; glans of male genital tubercle; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Rap1gds1 Products(12)

mRNA	Protein	Name
NM_001040690.3	NP_001035780.1	rap1 GTPase-GDP dissociation stimulator 1 isoform a
NM_001286759.2	NP_001273688.1	rap1 GTPase-GDP dissociation stimulator 1 isoform c
NM_001356388.2	NP_001343317.1	rap1 GTPase-GDP dissociation stimulator 1 isoform d
NM_001411343.1	NP_001398272.1	rap1 GTPase-GDP dissociation stimulator 1 isoform e
NM_001411344.1	NP_001398273.1	rap1 GTPase-GDP dissociation stimulator 1 isoform f
NM_001411345.1	NP_001398274.1	rap1 GTPase-GDP dissociation stimulator 1 isoform g
NM_001411346.1	NP_001398275.1	rap1 GTPase-GDP dissociation stimulator 1 isoform h
NM_001411347.1	NP_001398276.1	rap1 GTPase-GDP dissociation stimulator 1 isoform i
NM_001411348.1	NP_001398277.1	rap1 GTPase-GDP dissociation stimulator 1 isoform j
NM_001411349.1	NP_001398278.1	rap1 GTPase-GDP dissociation stimulator 1 isoform k
NM_001411350.1	NP_001398279.1	rap1 GTPase-GDP dissociation stimulator 1 isoform l
NM_145544.4	NP_663519.2	rap1 GTPase-GDP dissociation stimulator 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase regulator activity	IDA IDA: Inferred from direct assay	26975711	MGI
enables GTPase regulator activity	IMP IMP: Inferred from mutant phenotype	26975711	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiotensin-activated signaling pathway involved in heart process	IMP IMP: Inferred from mutant phenotype	26975711	MGI
acts upstream of or within cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	26975711	MGI
acts upstream of or within cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	26975711	MGI
acts upstream of or within negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	26975711	MGI
acts upstream of or within negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	26975711	MGI
acts upstream of or within regulation of ERK5 cascade	IMP IMP: Inferred from mutant phenotype	26975711	MGI
acts upstream of or within regulation of matrix metallopeptidase secretion	IMP IMP: Inferred from mutant phenotype	29921611	MGI
acts upstream of or within response to statin	IMP IMP: Inferred from mutant phenotype	26975711	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	26975711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rap1 GTPase-GDP dissociation stimulator 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11656	RAP1GDS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rap1gds1	NCBI	NCBI:5910

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