Rap1gds1 - RAP1, GTP-GDP dissociation stimulator 1 Gene

Also Known as GDS1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229877

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of GTPase activity; and positive regulation of mitochondrial calcium ion concentration. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; glans of male genital tubercle; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Rap1gds1 Products (12)

mRNA Protein Name
NM_001040690.3 NP_001035780.1 rap1 GTPase-GDP dissociation stimulator 1 isoform a
NM_001286759.2 NP_001273688.1 rap1 GTPase-GDP dissociation stimulator 1 isoform c
NM_001356388.2 NP_001343317.1 rap1 GTPase-GDP dissociation stimulator 1 isoform d
NM_001411343.1 NP_001398272.1 rap1 GTPase-GDP dissociation stimulator 1 isoform e
NM_001411344.1 NP_001398273.1 rap1 GTPase-GDP dissociation stimulator 1 isoform f
NM_001411345.1 NP_001398274.1 rap1 GTPase-GDP dissociation stimulator 1 isoform g
NM_001411346.1 NP_001398275.1 rap1 GTPase-GDP dissociation stimulator 1 isoform h
NM_001411347.1 NP_001398276.1 rap1 GTPase-GDP dissociation stimulator 1 isoform i
NM_001411348.1 NP_001398277.1 rap1 GTPase-GDP dissociation stimulator 1 isoform j
NM_001411349.1 NP_001398278.1 rap1 GTPase-GDP dissociation stimulator 1 isoform k
NM_001411350.1 NP_001398279.1 rap1 GTPase-GDP dissociation stimulator 1 isoform l
NM_145544.4 NP_663519.2 rap1 GTPase-GDP dissociation stimulator 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase regulator activity IDA
IDA: Inferred from direct assay
26975711 MGI
enables GTPase regulator activity IMP
IMP: Inferred from mutant phenotype
26975711 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiotensin-activated signaling pathway involved in heart process IMP
IMP: Inferred from mutant phenotype
26975711 MGI
acts upstream of or within cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
26975711 MGI
acts upstream of or within cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
26975711 MGI
acts upstream of or within negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
26975711 MGI
acts upstream of or within negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
26975711 MGI
acts upstream of or within regulation of ERK5 cascade IMP
IMP: Inferred from mutant phenotype
26975711 MGI
acts upstream of or within regulation of matrix metallopeptidase secretion IMP
IMP: Inferred from mutant phenotype
29921611 MGI
acts upstream of or within response to statin IMP
IMP: Inferred from mutant phenotype
26975711 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
26975711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rap1 GTPase-GDP dissociation stimulator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11656 RAP1GDS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rap1gds1 NCBI NCBI:5910