2. Gene
  3. RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 Gene

RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GDS1; SmgGDS

Gene ID: 5910 | Gene type: protein coding

About RAP1GDS1

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,261,384-98,443,858 (from NCBI)

This gene has 21 transcripts (splice variants), 207 orthologues and is associated with 64 phenotypes. Ubiquitous expression in brain (RPKM 27.0), testis (RPKM 10.3) and 25 other tissues.

Summary

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

RAP1GDS1 Products(6)

mRNA Protein Name
NM_001100426.2 NP_001093896.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 1
NM_001100427.2 NP_001093897.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 3
NM_001100428.2 NP_001093898.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 4
NM_001100429.2 NP_001093899.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 5
NM_001100430.2 NP_001093900.1 rap1 GTPase-GDP dissociation stimulator 1 isoform 6
NM_021159.5 NP_066982.3 rap1 GTPase-GDP dissociation stimulator 1 isoform 2

RAP1GDS1 Protein Structure

Arm

Arm: Armadillo/beta-catenin-like repeat (83 - 117)

Arm

Arm: Armadillo/beta-catenin-like repeat (169 - 210)

Arm

Arm: Armadillo/beta-catenin-like repeat (346 - 389)

Arm

Arm: Armadillo/beta-catenin-like repeat (481 - 518)

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  • 607 a.a.
Protein Preferred Names Protein Names

rap1 GTPase-GDP dissociation stimulator 1

RAP1, GTP-GDP dissociation stimulator 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11656 RAP1GDS1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAP1GDS1 VGNC VGNC:76659
Bos taurus RAP1GDS1 VGNC VGNC:33718
Mus musculus RAP1GDS1 MGD MGI:2385189
Rattus norvegicus RAP1GDS1 RGD RGD:1308558
Canis familiaris RAP1GDS1 VGNC VGNC:45343
Felis catus RAP1GDS1 VGNC VGNC:69237