Gtf2b - general transcription factor IIB Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229906

Summary

Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including RNA polymerase II core complex assembly; positive regulation of core promoter binding activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebral cortex; pancreas; and testis. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Apr 2022]

Gtf2b Products (1)

mRNA Protein Name
NM_145546.1 NP_663521.1 transcription initiation factor IIB

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
18722179 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22323595 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14612417 MGI
Biological Process GO Annotation Evidence References Source
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
24244602 MGI
involved in embryo development IMP
IMP: Inferred from mutant phenotype
24244602 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
24244602 MGI
involved in meiotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
24244602 MGI
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
24244602 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell division site IDA
IDA: Inferred from direct assay
24244602 MGI
is active in condensed chromosome IDA
IDA: Inferred from direct assay
24244602 MGI
is active in germinal vesicle IDA
IDA: Inferred from direct assay
24244602 MGI
is active in kinetochore IDA
IDA: Inferred from direct assay
24244602 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
24244602 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18722179 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription initiation factor IIB

  • RNA polymerase II alpha initiation factor

  • general transcription factor TFIIB

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05894 GTF2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21590 Gtf2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28108 Gtf2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gtf2b NCBI NCBI:2959