2. Gene
  3. GTF2B - general transcription factor IIB Gene

GTF2B - general transcription factor IIB Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TF2B; TFIIB

Gene ID: 2959 | Gene type: protein coding

About GTF2B

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:88,852,633-88,891,567 (from NCBI)

This gene has 7 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.5), gall bladder (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GTF2B Products(1)

mRNA Protein Name
NM_001514.6 NP_001505.1 transcription initiation factor IIB

GTF2B Protein Structure

TF_Zn_Ribbon

TF_Zn_Ribbon: TFIIB zinc-binding (14 - 55)

TFIIB

TFIIB: Transcription factor TFIIB repeat (121 - 191)

TFIIB

TFIIB: Transcription factor TFIIB repeat (215 - 285)

  • 0
  • 100
  • 200
  • 316 a.a.
Protein Preferred Names Protein Names

transcription initiation factor IIB

RNA polymerase II transcription factor IIB

Recombinant GTF2B Proteins

Cat. No. Product Name Accession Purity
HY-P71357 TFIIB Protein, Human (GST) Q00403 (M1-L316) ≥95%

Related Diseases

Diseases Alias
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05894 GTF2B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GTF2B VGNC VGNC:67493
Mus musculus GTF2B MGD MGI:2385191
Bos taurus GTF2B VGNC VGNC:29693
Rattus norvegicus GTF2B RGD RGD:619735
Macaca mulatta GTF2B VGNC VGNC:73306
Canis familiaris GTF2B VGNC VGNC:41543
Others GTF2B NCBI