SAP30 - Sin3A associated protein 30 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8819

About SAP30

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,370,954-173,377,532 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 10.9), stomach (RPKM 8.8) and 25 other tissues.

Summary

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and Other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

SAP30 Products (1)

mRNA	Protein	Name
NM_003864.4	NP_003855.1	histone deacetylase complex subunit SAP30

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9651585	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9651585	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in modulation by host of symbiont transcription	IDA IDA: Inferred from direct assay	21221920	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9651585	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	9651585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAP30 Protein Structure

zf-SAP30

SAP30_Sin3_bdg

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
histone deacetylase complex subunit SAP30	30 kDa Sin3-associated polypeptide

SAP30 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SAP30	O75446	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	SAP30	O75446	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	SAP30	O75446	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	SAP30	O75446	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	SAP30	O75446	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	SAP30	O75446	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	SAP30	O75446	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	SAP30	O75446	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	SAP30	O75446	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

SAP30 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810140	SAP 30 Antibody (YA9484)	ICC/IF, IF-Tissue, IHC-P, ELISA	human

Related Diseases

Diseases	Alias
Phlebotomus Fever	Pappataci Fever Sandfly Fever Sandfly-Borne Phleboviral Disease Sandfly-Borne Arboviral Fever Sandfly-Borne Bunyavirus Fever Three Day Fever Chitral Fever Italy Summer Grippe Italy Summer Grippe Influenza
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Rift Valley Fever	Rfv - [Rift Valley Fever]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12440	SAP30 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12441	SAP30BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21751	Sap30 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28269	Sap30 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SAP30	VGNC	VGNC:76968
Mus musculus	SAP30	MGD	MGI:1929129
Canis familiaris	SAP30	VGNC	VGNC:45860
Rattus norvegicus	SAP30	RGD	RGD:1595501
Felis catus	SAP30	VGNC	VGNC:64869
Bos taurus	SAP30	VGNC	VGNC:34282
Others	SAP30	NCBI