LIMCH1 - LIM and calponin homology domains 1 Gene

Also Known as LMO7B; LIMCH1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22998

About LIMCH1

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,359,607-41,700,044 (from NCBI)

This gene has 22 transcripts (splice variants), 243 orthologues and 1 paralogue. Broad expression in lung (RPKM 19.3), spleen (RPKM 14.7) and 20 other tissues.

Summary

Enables Myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with Myosin II complex. [provided by Alliance of Genome Resources, Apr 2022]

LIMCH1 Products (20)

mRNA Protein Name
NM_001112717.4 NP_001106188.1 LIM and calponin homology domains-containing protein 1 isoform b
NM_001112718.4 NP_001106189.1 LIM and calponin homology domains-containing protein 1 isoform c
NM_001112719.4 NP_001106190.1 LIM and calponin homology domains-containing protein 1 isoform d
NM_001112720.4 NP_001106191.1 LIM and calponin homology domains-containing protein 1 isoform e
NM_001289122.3 NP_001276051.1 LIM and calponin homology domains-containing protein 1 isoform f
NM_001289124.2 NP_001276053.1 LIM and calponin homology domains-containing protein 1 isoform g
NM_001330672.2 NP_001317601.1 LIM and calponin homology domains-containing protein 1 isoform h
NM_001330674.2 NP_001317603.1 LIM and calponin homology domains-containing protein 1 isoform i
NM_001330784.2 NP_001317713.1 LIM and calponin homology domains-containing protein 1 isoform j
NM_001330786.2 NP_001317715.1 LIM and calponin homology domains-containing protein 1 isoform k
NM_001330787.2 NP_001317716.1 LIM and calponin homology domains-containing protein 1 isoform l
NM_001330788.2 NP_001317717.1 LIM and calponin homology domains-containing protein 1 isoform m
NM_001330789.2 NP_001317718.1 LIM and calponin homology domains-containing protein 1 isoform n
NM_001330790.2 NP_001317719.1 LIM and calponin homology domains-containing protein 1 isoform o
NM_001330791.2 NP_001317720.1 LIM and calponin homology domains-containing protein 1 isoform p
NM_001330792.2 NP_001317721.1 LIM and calponin homology domains-containing protein 1 isoform q
NM_001330793.2 NP_001317722.1 LIM and calponin homology domains-containing protein 1 isoform r
NM_001330982.2 NP_001317911.1 LIM and calponin homology domains-containing protein 1 isoform s
NM_001330983.1 NP_001317912.1 LIM and calponin homology domains-containing protein 1 isoform t
NM_014988.5 NP_055803.2 LIM and calponin homology domains-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables myosin II head/neck binding IDA
IDA: Inferred from direct assay
28228547 GOA
enables myosin II head/neck binding IPI
IPI: Inferred from physical interaction
28228547 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30429017 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic actin-based contraction involved in cell motility IMP
IMP: Inferred from mutant phenotype
28228547 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
28228547 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
28228547 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
28228547 GOA
involved in regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
28228547 GOA
Cellular Component GO Annotation Evidence References Source
part of myosin II complex IDA
IDA: Inferred from direct assay
28228547 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
28228547 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMCH1 Protein Structure

CH

CH: Calponin homology (CH) domain (28 - 133)

LIM

LIM: LIM domain (1013 - 1074)

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  • 1000
  • 1083 a.a.
Protein Preferred Names Protein Names

LIM and calponin homology domains-containing protein 1

LIMCH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIMCH1 Q9UPQ0 KLHL15 Homo sapiens Q96M94
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07658 LIMCH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LIMCH1 VGNC VGNC:42678
Mus musculus LIMCH1 MGD MGI:1924819
Felis catus LIMCH1 VGNC VGNC:63229
Bos taurus LIMCH1 VGNC VGNC:30887
Macaca mulatta LIMCH1 VGNC VGNC:74155
Rattus norvegicus LIMCH1 RGD RGD:1305269