Aldob - aldolase B, fructose-bisphosphate Gene

Also Known as Aldo2; Aldo-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230163

Summary

This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]

Aldob Products (1)

mRNA Protein Name
NM_144903.3 NP_659152.1 fructose-bisphosphate aldolase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fructose-1-phosphate aldolase activity IMP
IMP: Inferred from mutant phenotype
25637246 MGI
enables fructose-bisphosphate aldolase activity IDA
IDA: Inferred from direct assay
604178 MGI
enables fructose-bisphosphate aldolase activity IMP
IMP: Inferred from mutant phenotype
25637246 MGI
Biological Process GO Annotation Evidence References Source
involved in fructose catabolic process IDA
IDA: Inferred from direct assay
4343087 MGI
involved in fructose catabolic process IMP
IMP: Inferred from mutant phenotype
29533924 MGI
involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IMP
IMP: Inferred from mutant phenotype
29533924 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
32733884 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fructose-bisphosphate aldolase B

  • liver-type aldolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17969 Aldob Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00584 ALDOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24440 Aldob Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldob NCBI NCBI:229