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ALDOB - aldolase, fructose-bisphosphate B Gene

Also Known as ALDB; ALDO2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 229

About ALDOB

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,420,560-101,435,774 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 2378.7), small intestine (RPKM 1833.7) and 2 other tissues.

Summary

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and Other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

ALDOB Products (1)

mRNA	Protein	Name
NM_000035.4	NP_000026.2	fructose-bisphosphate aldolase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	17576770	GOA
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	9244396	GOA
enables fructose binding	IMP IMP: Inferred from mutant phenotype	10625657	GOA
enables fructose-1-phosphate aldolase activity	IDA IDA: Inferred from direct assay	2649152	GOA
enables fructose-bisphosphate aldolase activity	IDA IDA: Inferred from direct assay	9244396	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10625657	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	35122041	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18000879	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NADH oxidation	IDA IDA: Inferred from direct assay	17576770	GOA
involved in fructose 1,6-bisphosphate metabolic process	IDA IDA: Inferred from direct assay	9244396	GOA
involved in fructose metabolic process	IMP IMP: Inferred from mutant phenotype	3383242	GOA
involved in glycolytic process	IDA IDA: Inferred from direct assay	10625657	GOA
involved in negative regulation of pentose-phosphate shunt	IMP IMP: Inferred from mutant phenotype	35122041	GOA
involved in positive regulation of ATP-dependent activity	IGI IGI: Inferred from genetic interaction	17576770	GOA
involved in vacuolar proton-transporting V-type ATPase complex assembly	IGI IGI: Inferred from genetic interaction	17576770	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	18000879	GOA
located in cytosol	IDA IDA: Inferred from direct assay	35122041	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	18000879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDOB Protein Structure

Glycolytic

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
fructose-bisphosphate aldolase B	aldolase 2

ALDOB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ALDOB	P05062	BBS1	Homo sapiens	Q8NFJ9	CoIP	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	Y2H	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	Confocal	18000879
Intra	ALDOB	P05062	BBS4	Homo sapiens	Q96RK4	CoIP	18000879
Intra	ALDOB	P05062	BBS7	Homo sapiens	Q8IWZ6	Confocal	18000879
Intra	ALDOB	P05062	BBS7	Homo sapiens	Q8IWZ6	CoIP	18000879
Intra	ALDOB	P05062	ALDOA	Homo sapiens	P04075	Anti Tag CoIP	33961781
Intra	ALDOB	P05062	ALDOA	Homo sapiens	P04075	Y2H	21988832
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	CoIP	18000879
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	Confocal	18000879
Intra	ALDOB	P05062	BBS2	Homo sapiens	Q9BXC9	Y2H	18000879

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDOB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74419	Aldolase B Protein, Human (GST, solution)	P05062 (A2-Y364)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Fructose Intolerance, Hereditary	Hereditary Fructose Intolerance Fructose Intolerance Fructose-1-Phosphate Aldolase Deficiency Fructose-1,6-Bisphosphate Aldolase B Deficiency Aldolase B Deficiency Fructosemia Aldob Deficiency Hereditary Fructose Intolerance Syndrome HFI Fructosaemia Hereditary Fructose-1-Phosphate Aldolase Deficiency Fructose Aldolase B Deficiency Fructose-1,6-Biphosphate Aldolase Deficiency Hereditary Fructosemia Fructosemia, Hereditary Hereditary Fructosaemia Fructose-Biphosphate Aldolase B Deficiency Fructose Intolerance Of Newborn Aldb - [Aldolase B] Deficiency Deficiency Of Fructose-Bisphosphate Aldolase
Fructosuria, Essential	Essential Fructosuria Ketohexokinase Deficiency Fructosuria Hepatic Fructokinase Deficiency Fructokinase Deficiency FRUCT Deficiency Of Fructokinase
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17969	Aldob Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00584	ALDOB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24440	Aldob Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ALDOB	VGNC	VGNC:69791
Felis catus	ALDOB	VGNC	VGNC:59740
Bos taurus	ALDOB	VGNC	VGNC:25822
Canis familiaris	ALDOB	VGNC	VGNC:37792
Rattus norvegicus	ALDOB	RGD	RGD:2090
Mus musculus	ALDOB	MGD	MGI:87995
Others	ALDOB	NCBI