ALDOB - aldolase, fructose-bisphosphate B Gene

Also Known as ALDB; ALDO2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 229

About ALDOB

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:101,420,560-101,435,774 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 2378.7), small intestine (RPKM 1833.7) and 2 other tissues.

Summary

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

ALDOB Products (1)

mRNA Protein Name
NM_000035.4 NP_000026.2 fructose-bisphosphate aldolase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATPase binding IDA
IDA: Inferred from direct assay
17576770 GOA
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
9244396 GOA
enables fructose binding IMP
IMP: Inferred from mutant phenotype
10625657 GOA
enables fructose-1-phosphate aldolase activity IDA
IDA: Inferred from direct assay
2649152 GOA
enables fructose-bisphosphate aldolase activity IDA
IDA: Inferred from direct assay
9244396 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10625657 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
35122041 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18000879 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in NADH oxidation IDA
IDA: Inferred from direct assay
17576770 GOA
involved in fructose 1,6-bisphosphate metabolic process IDA
IDA: Inferred from direct assay
9244396 GOA
involved in fructose metabolic process IMP
IMP: Inferred from mutant phenotype
3383242 GOA
involved in glycolytic process IDA
IDA: Inferred from direct assay
10625657 GOA
involved in negative regulation of pentose-phosphate shunt IMP
IMP: Inferred from mutant phenotype
35122041 GOA
involved in positive regulation of ATP-dependent activity IGI
IGI: Inferred from genetic interaction
17576770 GOA
involved in vacuolar proton-transporting V-type ATPase complex assembly IGI
IGI: Inferred from genetic interaction
17576770 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in centriolar satellite IDA
IDA: Inferred from direct assay
18000879 GOA
located in cytosol IDA
IDA: Inferred from direct assay
35122041 GOA
located in microtubule organizing center IDA
IDA: Inferred from direct assay
18000879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDOB Protein Structure

Glycolytic

Glycolytic: Fructose-bisphosphate aldolase class-I (15 - 364)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

fructose-bisphosphate aldolase B

  • aldolase 2

ALDOB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ALDOB P05062 BBS1 Homo sapiens Q8NFJ9
CoIP
18000879
Intra
ALDOB P05062 BBS4 Homo sapiens Q96RK4
Y2H
18000879
Intra
ALDOB P05062 BBS4 Homo sapiens Q96RK4
Confocal
18000879
Intra
ALDOB P05062 BBS4 Homo sapiens Q96RK4
CoIP
18000879
Intra
ALDOB P05062 BBS7 Homo sapiens Q8IWZ6
Confocal
18000879
Intra
ALDOB P05062 BBS7 Homo sapiens Q8IWZ6
CoIP
18000879
Intra
ALDOB P05062 ALDOA Homo sapiens P04075
Anti Tag CoIP
33961781
Intra
ALDOB P05062 ALDOA Homo sapiens P04075
Y2H
21988832
Intra
ALDOB P05062 BBS2 Homo sapiens Q9BXC9
CoIP
18000879
Intra
ALDOB P05062 BBS2 Homo sapiens Q9BXC9
Confocal
18000879
Intra
ALDOB P05062 BBS2 Homo sapiens Q9BXC9
Y2H
18000879
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDOB Proteins

製品番号 製品名 アクセッション番号 純度
HY-P74419 Aldolase B Protein, Human (GST, solution) P05062 (A2-Y364) ≥ 85%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Fructose Intolerance, Hereditary

  • Hereditary Fructose Intolerance

  • Fructose Intolerance

  • Fructose-1-Phosphate Aldolase Deficiency

  • Fructose-1,6-Bisphosphate Aldolase B Deficiency

  • Aldolase B Deficiency

  • Fructosemia

  • Aldob Deficiency

  • Hereditary Fructose Intolerance Syndrome

  • HFI

  • Fructosaemia

  • Hereditary Fructose-1-Phosphate Aldolase Deficiency

  • Fructose Aldolase B Deficiency

  • Fructose-1,6-Biphosphate Aldolase Deficiency

  • Hereditary Fructosemia

  • Fructosemia, Hereditary

  • Hereditary Fructosaemia

  • Fructose-Biphosphate Aldolase B Deficiency

  • Fructose Intolerance Of Newborn

  • Aldb - [Aldolase B] Deficiency

  • Deficiency Of Fructose-Bisphosphate Aldolase
Fructosuria, Essential

  • Essential Fructosuria

  • Ketohexokinase Deficiency

  • Fructosuria

  • Hepatic Fructokinase Deficiency

  • Fructokinase Deficiency

  • FRUCT

  • Deficiency Of Fructokinase
Hypoglycemia

  • Hypoglycaemia

  • Low Blood Sugar

  • Hypoglycaemia Nos

  • Spontaneous Hypoglycaemia

  • Nondiabetic Hypoglycaemia

  • Hypoglycaemic Disorder Nos

  • Hypoglycaemic Syndrome
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS17969 Aldob Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00584 ALDOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24440 Aldob Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta ALDOB VGNC VGNC:69791
Felis catus ALDOB VGNC VGNC:59740
Bos taurus ALDOB VGNC VGNC:25822
Canis familiaris ALDOB VGNC VGNC:37792
Rattus norvegicus ALDOB RGD RGD:2090
Mus musculus ALDOB MGD MGI:87995
Others ALDOB NCBI