Themis2 - thymocyte selection associated family member 2 Gene

Mus musculus

Also known as ICB-1

Gene ID: 230787 | Gene type: protein coding

About Themis2

Summary

Involved in regulation of B cell activation. Acts upstream of or within T cell receptor signaling pathway. Located in cytoplasm and nucleus. Orthologous to human THEMIS2 (thymocyte selection associated family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Themis2 Products(1)

mRNA	Protein	Name
NM_001033308.2	NP_001028480.1	protein THEMIS2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22732588	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22732588	MGI
involved in regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	24907343	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22732588	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22732588	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein THEMIS2

basement membrane-induced protein	induced by contact to basement membrane 1 protein
protein ICB-1	thymocyte-expressed molecule involved in selection protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14489	THEMIS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Themis2	NCBI	NCBI:9473

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