THEMIS2 - thymocyte selection associated family member 2 Gene

Also Known as ICB1; ICB-1; C1orf38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9473

About THEMIS2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,872,544-27,886,675 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 58.1), spleen (RPKM 43.6) and 17 other tissues.

Summary

Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

THEMIS2 Products (5)

mRNA Protein Name
NM_001039477.3 NP_001034566.1 protein THEMIS2 isoform 2
NM_001105556.3 NP_001099026.1 protein THEMIS2 isoform 3
NM_001286113.2 NP_001273042.1 protein THEMIS2 isoform 4
NM_001286115.2 NP_001273044.1 protein THEMIS2 isoform 5
NM_004848.4 NP_004839.2 protein THEMIS2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEMIS2 Protein Structure

CABIT

CABIT: Cell-cycle sustaining, positive selection, (18 - 249)

CABIT

CABIT: Cell-cycle sustaining, positive selection, (286 - 520)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

protein THEMIS2

  • basement membrane-induced

THEMIS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THEMIS2 Q5TEJ8 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

THEMIS2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811324 ICB1 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Endometrial Adenocarcinoma

  • Endometrial Endometrioid Adenocarcinoma

  • Endometrial Adenoacanthoma

  • Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

  • Adenocarcinoma Of Endometrium

  • Adenocarcinoma Of The Endometrium

  • Adenocarcinoma Of Uterus

  • Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

  • Endometrioid Adenoma Or Carcinoma

  • Endometrioid Adenomas And Carcinomas

  • Endometrioid Carcinoma Of Endometrium

  • Endometrium Adenocarcinoma
Xia-Gibbs Syndrome

  • Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome

  • XIGIS

  • Mrd25

  • Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome

  • Mental Retardation, Autosomal Dominant 25, Formerly

  • Mrd25, Formerly

  • Autosomal Dominant Mental Retardation 25

  • Autosomal Dominant Intellectual Disability 25

  • Xgs
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14489 THEMIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus THEMIS2 RGD RGD:1561016
Bos taurus THEMIS2 VGNC VGNC:35836
Mus musculus THEMIS2 MGD MGI:2446213
Macaca mulatta THEMIS2 VGNC VGNC:78397
Canis familiaris THEMIS2 VGNC VGNC:47344
Felis catus THEMIS2 VGNC VGNC:66162
Others THEMIS2 NCBI