ICB1 Antibody
(Synonyms: C1orf38, ICB1, THEMIS2, Protein THEMIS2, Induced by contact to basement membrane 1 protein, Thymocyte-expressed molecule involved in selection protein 2, Protein ICB-1)ICB1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ICB1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
ICB1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ICB1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 72 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 13; 29; 50; 56; 57; 72 kDa
Purified recombinant protein of human ICB1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ICB1 may constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity)[1].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
Induction: By contact to a reconstituted basement membrane. -
Isoforms & Post-Translational Modification
ICB1 has 6 isoforms, Q5TEJ8-1: amino acid length is 643, molecular weight is 72049 Da (predicted); Q5TEJ8-2: amino acid length is 260, molecular weight is 29118 Da (predicted); Q5TEJ8-3: amino acid length is 498, molecular weight is 56130 Da (predicted); Q5TEJ8-4: amino acid length is 123, molecular weight is 13628 Da (predicted); Q5TEJ8-5: amino acid length is 514, molecular weight is 57943 Da (predicted); Q5TEJ8-6: amino acid length is 447, molecular weight is 50028 Da (predicted).Tyr-632 位点的磷酸化由脂多糖(LPS)诱导。B 细胞受体(BCR)激活后，会被 Src 激酶(Lck 或 Fyn)磷酸化ICB1 存在 6 个异构体，Q5TEJ8-1：氨基酸个数为 643 个，分子量为 72049 Da (预测)；Q5TEJ8-2：氨基酸个数为 260 个，分子量为 29118 Da (预测)；Q5TEJ8-3：氨基酸个数为 498 个，分子量为 56130 Da (预测)；Q5TEJ8-4：氨基酸个数为 123 个，分子量为 13628 Da (预测)；Q5TEJ8-5：氨基酸个数为 514 个，分子量为 57943 Da (预测)；Q5TEJ8-6：氨基酸个数为 447 个，分子量为 50028 Da (预测)。Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement
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Subunit
Interacts with VAV1.
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SwissProt ID
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Synonyms
C1orf38, ICB1, THEMIS2, Protein THEMIS2, Induced by contact to basement membrane 1 protein, Thymocyte-expressed molecule involved in selection protein 2, Protein ICB-1
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