Eif4g3 - eukaryotic translation initiation factor 4 gamma, 3 Gene

Mus musculus

Also known as repro8; Gm32394; eIF4GII; G1-419-52; 1500002J22Rik; 4930523M17Rik

Gene ID: 230861 | Gene type: protein coding

About Eif4g3

Summary

Predicted to enable mRNA binding activity and translation initiation factor activity. Acts upstream of or within positive regulation of cellular protein metabolic process; positive regulation of meiosis I; and spermatogenesis. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in nervous system; neural retina; and submandibular gland primordium. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]

Eif4g3 Products(7)

mRNA	Protein	Name
NM_001256195.1	NP_001243124.1	eukaryotic translation initiation factor 4 gamma 3 isoform 2
NM_001256198.1	NP_001243127.1	eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001355699.1	NP_001342628.1	eukaryotic translation initiation factor 4 gamma 3 isoform 4
NM_001355700.1	NP_001342629.1	eukaryotic translation initiation factor 4 gamma 3 isoform 5
NM_001369130.1	NP_001356059.1	eukaryotic translation initiation factor 4 gamma 3 isoform 6
NM_001369131.1	NP_001356060.1	eukaryotic translation initiation factor 4 gamma 3 isoform 7
NM_172703.3	NP_766291.2	eukaryotic translation initiation factor 4 gamma 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19114715	MGI
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	35951695	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of meiosis I	IMP IMP: Inferred from mutant phenotype	20430745	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20430745	MGI
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	35951695	MGI
acts upstream of or within positive regulation of translation	IMP IMP: Inferred from mutant phenotype	20430745	MGI
involved in spermatid development	IDA IDA: Inferred from direct assay	35951695	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	20430745	MGI
acts upstream of translation	IMP IMP: Inferred from mutant phenotype	20430745	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	35951695	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4 gamma 3

eIF-4-gamma 3

eIF-4-gamma II

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04283	EIF4G3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4g3	NCBI	NCBI:8672

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