2. Gene
  3. EIF4G3 - eukaryotic translation initiation factor 4 gamma 3 Gene

EIF4G3 - eukaryotic translation initiation factor 4 gamma 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as eIF4G 3; eIF4GII; eIF-4G 3

Gene ID: 8672 | Gene type: protein coding

About EIF4G3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,806,292-21,176,897 (from NCBI)

This gene has 23 transcripts (splice variants), 230 orthologues and 2 paralogues. Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues.

Summary

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a MicroRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

EIF4G3 Products(20)

mRNA Protein Name
NM_001198801.2 NP_001185730.1 eukaryotic translation initiation factor 4 gamma 3 isoform 1
NM_001198802.2 NP_001185731.1 eukaryotic translation initiation factor 4 gamma 3 isoform 2
NM_001198803.2 NP_001185732.1 eukaryotic translation initiation factor 4 gamma 3 isoform 4
NM_001391892.1 NP_001378821.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391893.1 NP_001378822.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391894.1 NP_001378823.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391895.1 NP_001378824.1 eukaryotic translation initiation factor 4 gamma 3 isoform 5
NM_001391896.1 NP_001378825.1 eukaryotic translation initiation factor 4 gamma 3 isoform 6
NM_001391897.1 NP_001378826.1 eukaryotic translation initiation factor 4 gamma 3 isoform 7
NM_001391898.1 NP_001378827.1 eukaryotic translation initiation factor 4 gamma 3 isoform 8
NM_001391899.1 NP_001378828.1 eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391900.1 NP_001378829.1 eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391901.1 NP_001378830.1 eukaryotic translation initiation factor 4 gamma 3 isoform 10
NM_001391902.1 NP_001378831.1 eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391903.1 NP_001378832.1 eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391904.1 NP_001378833.1 eukaryotic translation initiation factor 4 gamma 3 isoform 12
NM_001391905.1 NP_001378834.1 eukaryotic translation initiation factor 4 gamma 3 isoform 13
NM_001391906.1 NP_001378835.1 eukaryotic translation initiation factor 4 gamma 3 isoform 14
NM_001391907.1 NP_001378836.1 eukaryotic translation initiation factor 4 gamma 3 isoform 15
NM_003760.4 NP_003751.2 eukaryotic translation initiation factor 4 gamma 3 isoform 3

EIF4G3 Protein Structure

MIF4G

MIF4G: MIF4G domain (756 - 981)

MA3

MA3: MA3 domain (1222 - 1333)

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (1505 - 1584)

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  • 900
  • 1200
  • 1585 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4 gamma 3

eIF-4-gamma 3

Related Diseases

Diseases Alias
Bardet-Biedl Syndrome 9

BBS9

Bardet-Biedl Syndrome, Type 9
Vulto-Van Silfhout-De Vries Syndrome

Vulto-Van Silfout-De Vries Syndrome

VSVS

Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures

Iddisbas

Mrd24

Mental Retardation, Autosomal Dominant 24

Autosomal Dominant Mental Retardation 24

Autosomal Dominant Non-Syndromic Intellectual Disability 24

Mental Retardation, Autosomal Dominant, Type 24
Mouth Disease

Mouth Diseases

Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF4G3 VGNC VGNC:28417
Macaca mulatta EIF4G3 VGNC VGNC:99900
Mus musculus EIF4G3 MGD MGI:1923935
Rattus norvegicus EIF4G3 RGD RGD:1311370
Canis familiaris EIF4G3 VGNC VGNC:40290
Felis catus EIF4G3 VGNC VGNC:61796