EIF4G3 - eukaryotic translation initiation factor 4 gamma 3 Gene

Also Known as eIF4G 3; eIF4GII; eIF-4G 3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8672

About EIF4G3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,806,292-21,176,897 (from NCBI)

This gene has 23 transcripts (splice variants), 230 orthologues and 2 paralogues. Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues.

Summary

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a MicroRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

EIF4G3 Products (20)

mRNA	Protein	Name
NM_001198801.2	NP_001185730.1	eukaryotic translation initiation factor 4 gamma 3 isoform 1
NM_001198802.2	NP_001185731.1	eukaryotic translation initiation factor 4 gamma 3 isoform 2
NM_001198803.2	NP_001185732.1	eukaryotic translation initiation factor 4 gamma 3 isoform 4
NM_001391892.1	NP_001378821.1	eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391893.1	NP_001378822.1	eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391894.1	NP_001378823.1	eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391895.1	NP_001378824.1	eukaryotic translation initiation factor 4 gamma 3 isoform 5
NM_001391896.1	NP_001378825.1	eukaryotic translation initiation factor 4 gamma 3 isoform 6
NM_001391897.1	NP_001378826.1	eukaryotic translation initiation factor 4 gamma 3 isoform 7
NM_001391898.1	NP_001378827.1	eukaryotic translation initiation factor 4 gamma 3 isoform 8
NM_001391899.1	NP_001378828.1	eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391900.1	NP_001378829.1	eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391901.1	NP_001378830.1	eukaryotic translation initiation factor 4 gamma 3 isoform 10
NM_001391902.1	NP_001378831.1	eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391903.1	NP_001378832.1	eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391904.1	NP_001378833.1	eukaryotic translation initiation factor 4 gamma 3 isoform 12
NM_001391905.1	NP_001378834.1	eukaryotic translation initiation factor 4 gamma 3 isoform 13
NM_001391906.1	NP_001378835.1	eukaryotic translation initiation factor 4 gamma 3 isoform 14
NM_001391907.1	NP_001378836.1	eukaryotic translation initiation factor 4 gamma 3 isoform 15
NM_003760.4	NP_003751.2	eukaryotic translation initiation factor 4 gamma 3 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20212144	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	18426977	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4G3 Protein Structure

MIF4G

MA3

W2

0
300
600
900
1200
1500
1585 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 4 gamma 3	eIF-4-gamma 3

Related Diseases

Diseases	Alias
Bardet-Biedl Syndrome 9	BBS9 Bardet-Biedl Syndrome, Type 9
Vulto-Van Silfhout-De Vries Syndrome	Vulto-Van Silfout-De Vries Syndrome VSVS Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures Iddisbas Mrd24 Mental Retardation, Autosomal Dominant 24 Autosomal Dominant Mental Retardation 24 Autosomal Dominant Non-Syndromic Intellectual Disability 24 Mental Retardation, Autosomal Dominant, Type 24
Mouth Disease	Mouth Diseases Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04283	EIF4G3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EIF4G3	VGNC	VGNC:28417
Macaca mulatta	EIF4G3	VGNC	VGNC:99900
Mus musculus	EIF4G3	MGD	MGI:1923935
Rattus norvegicus	EIF4G3	RGD	RGD:1311370
Canis familiaris	EIF4G3	VGNC	VGNC:40290
Felis catus	EIF4G3	VGNC	VGNC:61796
Others	EIF4G3	NCBI