Samd11 - sterile alpha motif domain containing 11 Gene

Mus musculus

Also known as mr-s

Gene ID: 231004 | Gene type: protein coding

About Samd11

Summary

Enables PH domain binding activity; SAM domain binding activity; and protein self-association. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in photoreceptor layer; pineal gland; retina; retina layer; and retina outer nuclear layer. Orthologous to human SAMD11 (sterile alpha motif domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]

Samd11 Products(2)

mRNA	Protein	Name
NM_001110516.2	NP_001103986.1	sterile alpha motif domain-containing protein 11 isoform 1
NM_001355709.1	NP_001342638.1	sterile alpha motif domain-containing protein 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	33603070	MGI
enables PH domain binding	IDA IDA: Inferred from direct assay	16539743	MGI
enables SAM domain binding	IDA IDA: Inferred from direct assay	16539743	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16539743	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	33603070	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16539743	MGI
involved in retinal rod cell development	IMP IMP: Inferred from mutant phenotype	33603070	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	33603070	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16539743	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterile alpha motif domain-containing protein 11

SAM domain-containing protein 11

major retinal SAM domain-containing protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12423	SAMD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Samd11	NCBI	NCBI:148398

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