DCUN1D4 - defective in cullin neddylation 1 domain containing 4 Gene

Also Known as DCNL4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23142

About DCUN1D4

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:51,833,884-51,916,837 (from NCBI)

This gene has 22 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 10.1), adrenal (RPKM 8.7) and 25 other tissues.

Summary

Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D4 Products (4)

mRNA Protein Name
NM_001040402.3 NP_001035492.1 DCN1-like protein 4 isoform 1
NM_001287755.1 NP_001274684.1 DCN1-like protein 4 isoform 3
NM_001287757.2 NP_001274686.1 DCN1-like protein 4 isoform 4
NM_015115.4 NP_055930.2 DCN1-like protein 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cullin family protein binding IMP
IMP: Inferred from mutant phenotype
23201271 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21911577 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein neddylation IMP
IMP: Inferred from mutant phenotype
23201271 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IMP
IMP: Inferred from mutant phenotype
26906416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCUN1D4 Protein Structure

Cullin_binding

Cullin_binding: Cullin binding (174 - 287)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

DCN1-like protein 4

  • DCN1, defective in cullin neddylation 1, domain containing 4

DCUN1D4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
DCUN1D4 Q92564 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
Cross
DCUN1D4 Q92564 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Split-Luc
21911577
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03599 DCUN1D4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DCUN1D4 VGNC VGNC:39824
Mus musculus DCUN1D4 MGD MGI:2140972
Felis catus DCUN1D4 VGNC VGNC:61383
Rattus norvegicus DCUN1D4 RGD RGD:1310422
Bos taurus DCUN1D4 VGNC VGNC:53698
Macaca mulatta DCUN1D4 VGNC VGNC:71809
Others DCUN1D4 NCBI