Chfr - checkpoint with forkhead and ring finger domains Gene

Also Known as RNF116; C230082M18; 5730484M20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231600

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and protein destabilization. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Apr 2022]

Chfr Products (5)

mRNA Protein Name
NM_001289577.1 NP_001276506.1 E3 ubiquitin-protein ligase CHFR isoform 1
NM_001289578.1 NP_001276507.1 E3 ubiquitin-protein ligase CHFR isoform 3
NM_001289579.1 NP_001276508.1 E3 ubiquitin-protein ligase CHFR isoform 4
NM_001289580.1 NP_001276509.1 E3 ubiquitin-protein ligase CHFR isoform 5
NM_172717.4 NP_766305.2 E3 ubiquitin-protein ligase CHFR isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15793587 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
15793587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15793587 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
22285184 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
22285184 MGI
acts upstream of or within protein destabilization IDA
IDA: Inferred from direct assay
22285184 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
15793587 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15793587 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CHFR

  • RING-type E3 ubiquitin transferase CHFR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02623 CHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chfr NCBI NCBI:55743