Cyp26b1 - cytochrome P450, family 26, subfamily b, polypeptide 1 Gene

Mus musculus

Also known as CP26; P450RAI-2

Gene ID: 232174 | Gene type: protein coding

About Cyp26b1

Summary

Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; and retinoic acid binding activity. Involved in positive regulation of gene expression; positive regulation of tongue muscle cell differentiation; and tongue morphogenesis. Acts upstream of or within several processes, including cellular response to retinoic acid; male gamete generation; and skin development. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human CYP26B1 (Cytochrome P450 family 26 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp26b1 Products(2)

mRNA	Protein	Name
NM_001177713.1	NP_001171184.1	cytochrome P450 26B1
NM_175475.3	NP_780684.1	cytochrome P450 26B1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell fate determination	IMP IMP: Inferred from mutant phenotype	16574820	MGI
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	18816858	MGI
acts upstream of or within cornification	IMP IMP: Inferred from mutant phenotype	22366455	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	15030763	MGI
acts upstream of or within establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	23991089	MGI
acts upstream of or within establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	22366455	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	23991089	MGI
acts upstream of or within male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	16574820	MGI
acts upstream of or within negative regulation of retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22366455	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18816858	MGI
involved in positive regulation of tongue muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	18816858	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	15030763	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	23991089	MGI
acts upstream of or within regulation of retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23991089	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	15030763	MGI
acts upstream of retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22366455	MGI
involved in retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18816858	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16574820	MGI
involved in tongue morphogenesis	IMP IMP: Inferred from mutant phenotype	18816858	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 26B1

cytochrome P450 retinoic acid-inactivating 2	cytochrome P450, 26, retinoic acid B1
cytochrome P450RAI-2	retinoic acid B1
retinoic acid hydroxylase

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14531	Talarozole	Inhibitor	99.75%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182728	CD564	Inhibitor	/	Unkown
HY-RS03448	CYP26B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp26b1	NCBI	NCBI:56603

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