CD564
CD564 (Compound 11b) is a cytochrome P450 CYP26A1 and CYP26B1 inhibitor, with IC50 values of 1.63 μM and 0.52 μM, respectively. Cytochrome P450 CYP26 enzymes clear all-trans retinoic acid (atRA).
For research use only. We do not sell to patients.
- CAS No.: 110952-26-6
- Formula: C26H26O3
- Molecular Weight:386.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CYP26A1 1.63 μM (IC50) |
CYP26B1 0.52 μM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.52 μM
Compound: 11b
|
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
|
[PMID: 26918322] |
In Vitro
CD564 (1 min for CYP26A1, 5 min for CYP26B1) exhibits stronger inhibitory activity against CYP26B1 (IC50 = 0.52 μM) than against CYP26A1 (IC50 = 1.63 μM) in recombinant microsome assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 110952-26-6
-
Molecular Weight 386.48
-
Formula C26H26O3
-
SMILES
O=C(C1=CC2=CC=C(C(C3=CC=C4C(C(C)(CCC4(C)C)C)=C3)=O)C=C2C=C1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD564 Related Classifications
HY-182728 Related Classifications
Powered by Bioz