Tmf1 - TATA element modulatory factor 1 Gene

Mus musculus

Also known as Gm153; Tmf1`; 7030402D04Rik

Gene ID: 232286 | Gene type: protein coding

About Tmf1

Summary

Predicted to enable Androgen Receptor binding activity and nuclear receptor coactivator activity. Involved in regulation of proteasomal protein catabolic process. Acts upstream of or within several processes, including Leydig cell differentiation; regulation of gene expression; and spermatid development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in mandible and maxilla. Orthologous to human TMF1 (TATA element modulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tmf1 Products(1)

mRNA	Protein	Name
NM_001081111.2	NP_001074580.1	TATA element modulatory factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16792503	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Leydig cell differentiation	IMP IMP: Inferred from mutant phenotype	23000399	MGI
acts upstream of or within acrosome assembly	IMP IMP: Inferred from mutant phenotype	20691678	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	23000399	MGI
acts upstream of or within cellular response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	22531781	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	22553199	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23000399	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	20691678	MGI
acts upstream of or within luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	23000399	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	20691678	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23000399	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22553199	MGI
acts upstream of or within positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	22553199	MGI
acts upstream of or within positive regulation of testosterone secretion	IMP IMP: Inferred from mutant phenotype	23000399	MGI
involved in regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	16792503	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	20691678	MGI
acts upstream of or within spermatid nucleus differentiation	IMP IMP: Inferred from mutant phenotype	20691678	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20691678	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23000399	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TATA element modulatory factor

TMF	androgen receptor coactivator 160 kDa protein
androgen receptor-associated protein of 160 kDa

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14754	TMF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmf1	NCBI	NCBI:7110

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