ZC3H7B - zinc finger CCCH-type containing 7B Gene

Also Known as RoXaN; ROXAN1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23264

About ZC3H7B

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,301,525-41,360,147 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 25.2), ovary (RPKM 25.2) and 25 other tissues.

Summary

This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

ZC3H7B Products (1)

mRNA Protein Name
NM_017590.6 NP_060060.3 zinc finger CCCH domain-containing protein 7B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables miRNA binding IDA
IDA: Inferred from direct assay
28431233 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15047801 GOA
Biological Process GO Annotation Evidence References Source
involved in miRNA processing IMP
IMP: Inferred from mutant phenotype
28431233 GOA
acts upstream of positive effect post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28431233 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H7B Protein Structure

TPR_11

TPR_11: TPR repeat (37 - 112)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (890 - 913)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

zinc finger CCCH domain-containing protein 7B

  • Rotavirus 'X' associated non-structural protein

ZC3H7B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
ZC3H7B Q9UGR2 nsp3_rots4 Rotavirus A Q00721
Anti Tag CoIP
15047801
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ossifying Fibromyxoid Tumor

  • Ossifying Fibromyxoid Tumour

  • Ossifying Fibromyxoma
Myxoid Leiomyosarcoma

  • Leiomyosarcoma, Myxoid
Endometrial Stromal Tumor

  • Endometrial Stromal Neoplasm

  • Endometrial Stromal Tumors
Endometrial Stromal Nodule
Cellular Leiomyoma
Microphthalmia, Syndromic 2

  • Oculofaciocardiodental Syndrome

  • Ofcd Syndrome

  • MCOPS2

  • Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects

  • Syndromic Microphthalmia 2

  • Anop2

  • Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome

  • Maa2

  • Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects

  • Syndromic Microphthalmia Type 2

  • Oculo-Facio-Cardio-Dental Syndrome

  • Anop2, Formerly

  • Maa2, Formerly

  • Microphthalmia Syndromic 2

  • Oculo Facio Cardio Dental Syndrome

  • Microphthalmia, Syndromic, 2

  • Marashi-Gorlin Syndrome

  • Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects

  • Microphthalmia, Syndromic, Type 2
Leiomyosarcoma

  • Leiomyosarcomas
Mesenchymal Cell Neoplasm

  • Benign Miscellaneous Mesenchymal Tumor

  • Mesenchymal Tumor

  • Mesenchymal Tumors
Kidney Clear Cell Sarcoma

  • Clear Cell Sarcoma Of Kidney

  • Childhood Kidney Clear Cell Sarcoma

  • Renal Clear Cell Sarcoma

  • Ccsk

  • Clear Cell Sarcoma Of The Kidney
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Kidney Sarcoma

  • Renal Sarcoma

  • Sarcoma Of Kidney
Syndromic Microphthalmia

  • Microphthalmia, Syndromic
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15995 ZC3H7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZC3H7B RGD RGD:1307064
Macaca mulatta ZC3H7B VGNC VGNC:79891
Mus musculus ZC3H7B MGD MGI:1328310
Bos taurus ZC3H7B VGNC VGNC:37109
Felis catus ZC3H7B VGNC VGNC:67189
Canis familiaris ZC3H7B VGNC VGNC:108223
Others ZC3H7B NCBI