FMO4 - flavin containing dimethylaniline monoxygenase 4 Gene

Homo sapiens

Also known as FMO2

Gene ID: 2329 | Gene type: protein coding

About FMO4

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,314,183-171,342,084 (from NCBI)

This gene has 5 transcripts (splice variants), 140 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues.

Summary

Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the Enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

FMO4 Products(1)

mRNA	Protein	Name
NM_002022.3	NP_002013.1	dimethylaniline monooxygenase [N-oxide-forming] 4

FMO4 Protein Structure

FMO-like

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

dimethylaniline monooxygenase [N-oxide-forming] 4

FMO 4

Related Diseases

Diseases

Alias

Trimethylaminuria

TMAU	Fish-Odor Syndrome
Fish Malodor Syndrome	Fish Odor Syndrome
Stale Fish Syndrome	Tmauria
Severe Primary Trimethylaminuria	Mesh
D008661	Fish Odour Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05008	FMO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FMO4	VGNC	VGNC:40919
Macaca mulatta	FMO4	VGNC	VGNC:72684
Rattus norvegicus	FMO4	RGD	RGD:628601
Mus musculus	FMO4	MGD	MGI:2429497
Bos taurus	FMO4	VGNC	VGNC:29052
Felis catus	FMO4	VGNC	VGNC:62310