FMO4 - flavin containing dimethylaniline monoxygenase 4 Gene

Also Known as FMO2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2329

About FMO4

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,314,183-171,342,084 (from NCBI)

This gene has 5 transcripts (splice variants), 140 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues.

Summary

Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

FMO4 Products (1)

mRNA Protein Name
NM_002022.3 NP_002013.1 dimethylaniline monooxygenase [N-oxide-forming] 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMO4 Protein Structure

FMO-like

FMO-like: Flavin-binding monooxygenase-like (2 - 531)

  • 0
  • 100
  • 200
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  • 500
  • 558 a.a.
Protein Preferred Names Protein Names

dimethylaniline monooxygenase [N-oxide-forming] 4

  • FMO 4

FMO4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FMO4 P31512 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
FMO4 P31512 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
FMO4 P31512 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trimethylaminuria

  • TMAU

  • Fish-Odor Syndrome

  • Fish Malodor Syndrome

  • Fish Odor Syndrome

  • Stale Fish Syndrome

  • Tmauria

  • Severe Primary Trimethylaminuria

  • Mesh

  • D008661

  • Fish Odour Syndrome
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05008 FMO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FMO4 VGNC VGNC:40919
Macaca mulatta FMO4 VGNC VGNC:72684
Rattus norvegicus FMO4 RGD RGD:628601
Mus musculus FMO4 MGD MGI:2429497
Bos taurus FMO4 VGNC VGNC:29052
Felis catus FMO4 VGNC VGNC:62310
Others FMO4 NCBI