Arhgap35 - Rho GTPase activating protein 35 Gene

Also Known as Grlf1; p190A; mKIAA1722; p190RhoGAP; 6430596G11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232906

Summary

Enables GTPase activator activity. Involved in several processes, including axon development; establishment or maintenance of actin Cytoskeleton polarity; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including negative regulation of Rho protein signal transduction; negative regulation of vascular permeability; and nervous system development. Located in actin cytoskeleton; ciliary basal body; and cytoplasm. Is expressed in central nervous system and eye. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35). [provided by Alliance of Genome Resources, Apr 2022]

Arhgap35 Products (1)

mRNA Protein Name
NM_172739.4 NP_766327.3 rho GTPase-activating protein 35

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
18502760 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
23595732 MGI
involved in axon guidance IDA
IDA: Inferred from direct assay
11283609 MGI
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
11283609 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
11044403 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
18502760 MGI
involved in central nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
11283609 MGI
involved in establishment or maintenance of actin cytoskeleton polarity IMP
IMP: Inferred from mutant phenotype
18502760 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
11044403 MGI
involved in mammary gland development IMP
IMP: Inferred from mutant phenotype
21945077 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
15084284 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
22357865 MGI
acts upstream of or within negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
17562701 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
11044403 MGI
involved in neuron projection guidance IMP
IMP: Inferred from mutant phenotype
11283609 MGI
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
26859289 MGI
acts upstream of or within positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
15084284 MGI
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
11283609 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18502760 MGI
involved in regulation of actin polymerization or depolymerization IMP
IMP: Inferred from mutant phenotype
26859289 MGI
involved in regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
11283609 MGI
acts upstream of or within regulation of cell shape IDA
IDA: Inferred from direct assay
11044403 MGI
involved in wound healing, spreading of cells IMP
IMP: Inferred from mutant phenotype
18502760 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11044403 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
26859289 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11044403 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GTPase-activating protein 35

  • P190 RhoGAP

  • glucocorticoid receptor DNA-binding factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00933 ARHGAP35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgap35 NCBI NCBI:2909