Arhgap35 - Rho GTPase activating protein 35 Gene

Mus musculus

Also known as Grlf1; p190A; mKIAA1722; p190RhoGAP; 6430596G11Rik

Gene ID: 232906 | Gene type: protein coding

About Arhgap35

Summary

Enables GTPase activator activity. Involved in several processes, including axon development; establishment or maintenance of actin Cytoskeleton polarity; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including negative regulation of Rho protein signal transduction; negative regulation of vascular permeability; and nervous system development. Located in actin cytoskeleton; ciliary basal body; and cytoplasm. Is expressed in central nervous system and eye. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35). [provided by Alliance of Genome Resources, Apr 2022]

Arhgap35 Products(1)

mRNA	Protein	Name
NM_172739.4	NP_766327.3	rho GTPase-activating protein 35

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	18502760	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	23595732	MGI
involved in axon guidance	IDA IDA: Inferred from direct assay	11283609	MGI
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	11283609	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	11044403	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18502760	MGI
involved in central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	11283609	MGI
involved in establishment or maintenance of actin cytoskeleton polarity	IMP IMP: Inferred from mutant phenotype	18502760	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	11044403	MGI
involved in mammary gland development	IMP IMP: Inferred from mutant phenotype	21945077	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	15084284	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	22357865	MGI
acts upstream of or within negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17562701	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	11044403	MGI
involved in neuron projection guidance	IMP IMP: Inferred from mutant phenotype	11283609	MGI
involved in positive regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	26859289	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	15084284	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	11283609	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18502760	MGI
involved in regulation of actin polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	26859289	MGI
involved in regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	11283609	MGI
acts upstream of or within regulation of cell shape	IDA IDA: Inferred from direct assay	11044403	MGI
involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	18502760	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11044403	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	26859289	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11044403	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho GTPase-activating protein 35

P190 RhoGAP

glucocorticoid receptor DNA-binding factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00933	ARHGAP35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgap35	NCBI	NCBI:2909

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