SLC9A8 - solute carrier family 9 member A8 Gene

Also Known as NHE8; NHE-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23315

About SLC9A8

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,812,828-49,892,242 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 8.0), testis (RPKM 5.3) and 25 other tissues.

Summary

Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

SLC9A8 Products (2)

mRNA	Protein	Name
NM_001260491.2	NP_001247420.1	sodium/hydrogen exchanger 8 isoform 1
NM_015266.3	NP_056081.1	sodium/hydrogen exchanger 8 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables potassium:proton antiporter activity	IDA IDA: Inferred from direct assay	15522866	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	15522866	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	15522866	GOA
involved in regulation of Golgi lumen acidification	IDA IDA: Inferred from direct assay	15522866	GOA
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	34288721	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	15522866	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	15522866	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	34288721	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	20719963	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	15522866	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC9A8 Protein Structure

Na_H_Exchanger

0
100
200
300
400
500
581 a.a.

Protein Preferred Names	Protein Names
sodium/hydrogen exchanger 8	Na(+)/H(+) exchanger 8

SLC9A8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC9A8	Q9Y2E8	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SLC9A8	Q9Y2E8	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Christianson Syndrome	X-Linked Angelman-Like Syndrome X-Linked Intellectual Disability, South African Type X-Linked Intellectual Disability-Craniofacial Dysmorphism-Epilepsy-Ophthalmoplegia-Cerebellar Atrophy Syndrome Mental Retardation, Microcephaly, Epilepsy, And Ataxia Syndrome Mental Retardation, X-Linked Syndromic, Christianson Type Mrxsch Angelman-Like Syndrome X-Linked Intellectual Disability Microcephaly Epilepsy And Ataxia Syndrome Intellectual Disability X-Linked Syndromic Christianson Type Mrxs Christianson X-Linked Intellectual Disability - Craniofacial Dysmorphism - Epilepsy - Ophthalmoplegia - Cerebellar Atrophy Angelman-Like Syndrome, X-Linked Intellectual Deficit, X-Linked, South African Type Mental Retardation X-Linked, South African Type Mental Retardation, X-Linked, Syndromic, Christianson Type
Corneal Dystrophy, Band-Shaped	Band Keratopathy Band-Shaped Keratopathy
Inflammatory Diarrhea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13347	SLC9A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC9A8	VGNC	VGNC:77749
Rattus norvegicus	SLC9A8	RGD	RGD:1308193
Bos taurus	SLC9A8	VGNC	VGNC:34946
Canis familiaris	SLC9A8	VGNC	VGNC:46490
Mus musculus	SLC9A8	MGD	MGI:1924281
Felis catus	SLC9A8	VGNC	VGNC:65439
Others	SLC9A8	NCBI