Gdpd5 - glycerophosphodiester phosphodiesterase domain containing 5 Gene

Also Known as Gde2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 233552

Summary

Enables glycerophosphocholine phosphodiesterase activity. Involved in negative regulation of Notch signaling pathway and positive regulation of cell cycle. Acts upstream of or within neuron differentiation; positive regulation of neuron differentiation; and regulation of timing of cell differentiation. Located in several cellular components, including axon; neuronal cell body; and perinuclear endoplasmic reticulum. Is expressed in several structures, including nervous system and neural retina. Orthologous to human GDPD5 (glycerophosphodiester phosphodiesterase domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Gdpd5 Products (4)

mRNA	Protein	Name
NM_001362166.1	NP_001349095.1	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1
NM_001362167.1	NP_001349096.1	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 2
NM_001362168.1	NP_001349097.1	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 3
NM_201352.3	NP_958740.2	glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycerophosphocholine phosphodiesterase activity	EXP EXP: Inferred from Experiment	18667693	MGI
enables glycerophosphocholine phosphodiesterase activity	IDA IDA: Inferred from direct assay	18667693	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21943603	MGI
acts upstream of or within cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	22951639	MGI
involved in negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	21943603	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21943603	MGI
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21943603	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	23329048	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	17275818	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	21943603	MGI
acts upstream of or within positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	23329048	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	21943603	MGI
acts upstream of or within regulation of timing of cell differentiation	IMP IMP: Inferred from mutant phenotype	22951639	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21943603	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	21943603	MGI
located in membrane	IDA IDA: Inferred from direct assay	17275818	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	21943603	MGI
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	18667693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glycerophosphodiester phosphodiesterase domain-containing protein 5	glycerophosphocholine phosphodiesterase GDPD5 glycerophosphodiester phosphodiesterase 2 phosphoinositide phospholipase C GDPD5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05365	GDPD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdpd5	NCBI	NCBI:81544