Helt - helt bHLH transcription factor Gene

Also Known as Mgn; Hesl; megane; Heslike; A830086M02

Species: Mus musculus

Gene Type: protein coding

Gene ID: 234219

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including nervous system development; regulation of transcription by RNA polymerase II; and suckling behavior. Located in nucleus. Part of transcription regulator complex. Is expressed in brain; future midbrain; genitourinary system; heart; and nose. Orthologous to human HELT (helt bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Helt Products (1)

mRNA	Protein	Name
NM_173789.4	NP_776150.2	hairy and enhancer of split-related protein HELT

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14764602	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14764602	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14764602	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14764602	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14764602	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14764602	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within GABAergic neuron differentiation	IGI IGI: Inferred from genetic interaction	15071116	MGI
acts upstream of or within GABAergic neuron differentiation in basal ganglia	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14764602	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22920256	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	16968817	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22920256	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16644143	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14764602	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hairy and enhancer of split-related protein HELT	HES/HEY-like transcription factor Hes-like transcription factor bHLH transcription factor megane mesencephalic GABAergic neurons enhancer of split related protein protein megane

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06117	HELT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Helt	NCBI	NCBI:391723