Inpp4b - inositol polyphosphate-4-phosphatase, type II Gene

Also Known as E130107I17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234515

Summary

Enables lipid binding activity; phosphatidylinositol bisphosphate Phosphatase activity; and phosphatidylinositol trisphosphate Phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of protein kinase B signaling. Located in Golgi apparatus. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Apr 2022]

Inpp4b Products (4)

mRNA Protein Name
NM_001024617.3 NP_001019788.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 2
NM_001297591.1 NP_001284520.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 1
NM_001297593.1 NP_001284522.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 3
NM_001297596.1 NP_001284525.1 type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipid binding IDA
IDA: Inferred from direct assay
16631325 MGI
enables phosphatidylinositol bisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
21982707 MGI
enables phosphatidylinositol trisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
21982707 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
21982707 MGI
acts upstream of or within negative regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
21982707 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
21982707 MGI
acts upstream of or within regulation of bone remodeling IMP
IMP: Inferred from mutant phenotype
21982707 MGI
acts upstream of or within regulation of nucleocytoplasmic transport IMP
IMP: Inferred from mutant phenotype
21982707 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
23078915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

type II inositol 3,4-bisphosphate 4-phosphatase

  • D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase

  • phosphatidylinositol-3,4-bisphosphate 4-phosphatase

  • phosphoinositide 4-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06826 INPP4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21875 Inpp4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28392 Inpp4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp4b NCBI NCBI:8821