INPP4B - inositol polyphosphate-4-phosphatase type II B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8821

About INPP4B

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:142,023,160-142,846,535 (from NCBI)

This gene has 25 transcripts (splice variants), 254 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 24 other tissues.

Summary

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the Enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

INPP4B Products (34)

mRNA Protein Name
NM_001101669.3 NP_001095139.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001331040.1 NP_001317969.1 inositol polyphosphate 4-phosphatase type II isoform 2
NM_001385334.1 NP_001372263.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385335.1 NP_001372264.1 inositol polyphosphate 4-phosphatase type II isoform 2
NM_001385336.1 NP_001372265.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385337.1 NP_001372266.1 inositol polyphosphate 4-phosphatase type II isoform 12
NM_001385338.1 NP_001372267.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385339.1 NP_001372268.1 inositol polyphosphate 4-phosphatase type II isoform 3
NM_001385340.1 NP_001372269.1 inositol polyphosphate 4-phosphatase type II isoform 14
NM_001385341.1 NP_001372270.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385342.1 NP_001372271.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385343.1 NP_001372272.1 inositol polyphosphate 4-phosphatase type II isoform 3
NM_001385344.1 NP_001372273.1 inositol polyphosphate 4-phosphatase type II isoform 1
NM_001385347.1 NP_001372276.1 inositol polyphosphate 4-phosphatase type II isoform 4
NM_001385348.1 NP_001372277.1 inositol polyphosphate 4-phosphatase type II isoform 4
NM_001385350.1 NP_001372279.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385351.1 NP_001372280.1 inositol polyphosphate 4-phosphatase type II isoform 6
NM_001385357.1 NP_001372286.1 inositol polyphosphate 4-phosphatase type II isoform 17
NM_001385362.1 NP_001372291.1 inositol polyphosphate 4-phosphatase type II isoform 18
NM_001385379.1 NP_001372308.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385380.1 NP_001372309.1 inositol polyphosphate 4-phosphatase type II isoform 13
NM_001385381.1 NP_001372310.1 inositol polyphosphate 4-phosphatase type II isoform 11
NM_001385382.1 NP_001372311.1 inositol polyphosphate 4-phosphatase type II isoform 9
NM_001385383.1 NP_001372312.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385450.1 NP_001372379.1 inositol polyphosphate 4-phosphatase type II isoform 15
NM_001385452.1 NP_001372381.1 inositol polyphosphate 4-phosphatase type II isoform 16
NM_001385454.1 NP_001372383.1 inositol polyphosphate 4-phosphatase type II isoform 19
NM_001385455.1 NP_001372384.1 inositol polyphosphate 4-phosphatase type II isoform 8
NM_001385457.1 NP_001372386.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_001385458.1 NP_001372387.1 inositol polyphosphate 4-phosphatase type II isoform 17
NM_001385459.1 NP_001372388.1 inositol polyphosphate 4-phosphatase type II isoform 7
NM_001385460.1 NP_001372389.1 inositol polyphosphate 4-phosphatase type II isoform 5
NM_001385461.1 NP_001372390.1 inositol polyphosphate 4-phosphatase type II isoform 10
NM_003866.3 NP_003857.2 inositol polyphosphate 4-phosphatase type II isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24407287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol polyphosphate 4-phosphatase type II

  • inositol polyphosphate 4-phosphatase II

INPP4B Antibodies

Cat. No. Product Name Application Reactivity
HY-P81491 INPP4B Antibody (YA1236) IHC-P Human
HY-P81491A INPP4B Antibody (YA1236)(PBS only)

Related Diseases

Diseases Alias
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06826 INPP4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21875 Inpp4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28392 Inpp4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta INPP4B VGNC VGNC:73748
Rattus norvegicus INPP4B RGD RGD:620470
Mus musculus INPP4B MGD MGI:2158925
Canis familiaris INPP4B VGNC VGNC:42029
Bos taurus INPP4B VGNC VGNC:53908
Felis catus INPP4B VGNC VGNC:67806
Others INPP4B NCBI