Tmem231 - transmembrane protein 231 Gene

Also Known as Gm178; 4932417I16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 234740

Summary

Acts upstream of or within several processes, including embryonic digit morphogenesis; neuroepithelial cell differentiation; and smoothened signaling pathway. Located in ciliary membrane and ciliary transition zone. Part of MKS complex. Is expressed in embryo. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231). [provided by Alliance of Genome Resources, Apr 2022]

Tmem231 Products (2)

mRNA	Protein	Name
NM_001033321.2	NP_001028493.1	transmembrane protein 231 isoform 1
NM_001357348.1	NP_001344277.1	transmembrane protein 231 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22179047	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	22179047	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	22179047	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	22179047	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	22179047	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of MKS complex	IDA IDA: Inferred from direct assay	22179047	MGI
located in ciliary membrane	IDA IDA: Inferred from direct assay	22179047	MGI
located in ciliary transition zone	IDA IDA: Inferred from direct assay	22179047	MGI
located in membrane	IDA IDA: Inferred from direct assay	22179047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 231

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14703	TMEM231 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem231	NCBI	NCBI:79583