Spire2 - spire type actin nucleation factor 2 Gene

Mus musculus

Also known as Spir2; Spir-2

Gene ID: 234857 | Gene type: protein coding

About Spire2

Summary

Predicted to enable actin binding activity. Involved in several processes, including Cytoskeleton organization; cytoskeleton-dependent cytokinesis; and intracellular transport. Located in cell cortex and cytoplasmic vesicle membrane. Colocalizes with cleavage furrow. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart ventricle; and limb. Orthologous to human SPIRE2 (spire type actin nucleation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Spire2 Products(1)

mRNA	Protein	Name
NM_172287.2	NP_758491.1	protein spire homolog 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in cleavage furrow formation	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in establishment of meiotic spindle localization	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in formin-nucleated actin cable assembly	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in intracellular transport	IMP IMP: Inferred from mutant phenotype	21983562	MGI
involved in polar body extrusion after meiotic divisions	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21983562	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	21983562	MGI
colocalizes with cleavage furrow	IDA IDA: Inferred from direct assay	21620703	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	21983562	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein spire homolog 2

spire homolog 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161011	Spire2-FMN2 PPI-IN-1	Inhibitor	/	Unkown
HY-161011A	Spire2-FMN2 PPI-IN-1 dihydrochloride	Inhibitor	98.99%	Unkown
HY-RS13688	SPIRE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spire2	NCBI	NCBI:84501

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