Spire2 - spire type actin nucleation factor 2 Gene

Also Known as Spir2; Spir-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234857

Summary

Predicted to enable actin binding activity. Involved in several processes, including Cytoskeleton organization; cytoskeleton-dependent cytokinesis; and intracellular transport. Located in cell cortex and cytoplasmic vesicle membrane. Colocalizes with cleavage furrow. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart ventricle; and limb. Orthologous to human SPIRE2 (spire type actin nucleation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Spire2 Products (1)

mRNA Protein Name
NM_172287.2 NP_758491.1 protein spire homolog 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in cleavage furrow formation IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in establishment of meiotic spindle localization IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in formin-nucleated actin cable assembly IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in intracellular transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
involved in polar body extrusion after meiotic divisions IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
21983562 MGI
colocalizes with cleavage furrow IDA
IDA: Inferred from direct assay
21620703 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
21983562 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein spire homolog 2

  • spire homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161011 Spire2-FMN2 PPI-IN-1 Inhibitor / Unkown
HY-161011A Spire2-FMN2 PPI-IN-1 dihydrochloride Inhibitor 98.99% Unkown
HY-RS13688 SPIRE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spire2 NCBI NCBI:84501