SPIRE2 - spire type actin nucleation factor 2 Gene

Also Known as Spir-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84501

About SPIRE2

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,828,475-89,871,319 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 1 paralogue. Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues.

Summary

Predicted to enable actin binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Predicted to colocalize with cleavage furrow. [provided by Alliance of Genome Resources, Apr 2022]

SPIRE2 Products (1)

mRNA Protein Name
NM_032451.2 NP_115827.1 protein spire homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21620703 GOA
involved in establishment of meiotic spindle localization IMP
IMP: Inferred from mutant phenotype
21620703 GOA
involved in formin-nucleated actin cable assembly IMP
IMP: Inferred from mutant phenotype
26287480 GOA
involved in positive regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
26287480 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein spire homolog 2

  • spire actin nucleation factor 2

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Familial Hypercholesterolemia

  • Hyperlipoproteinemia Type Iia

  • Familial Hyperbetalipoproteinaemia

  • Familial Hypercholesteremia

  • Fredrickson Type Iia Hyperlipoproteinemia

  • Fredrickson Type Iia Lipidaemia

  • Hyperbetalipoproteinemia

  • Type Ii Hyperlipidemia

  • Familial Hypercholesterolæmia

  • Familial Hypercholesterolaemia

  • Fh

  • Hypercholesterolemia Familial

  • Hyperlipoproteinemia Type Ii

  • Hypercholesterolemia, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161011 Spire2-FMN2 PPI-IN-1 Inhibitor / Unkown
HY-161011A Spire2-FMN2 PPI-IN-1 dihydrochloride Inhibitor 98.99% Unkown
HY-RS13688 SPIRE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPIRE2 MGD MGI:2446256
Felis catus SPIRE2 VGNC VGNC:65641
Macaca mulatta SPIRE2 VGNC VGNC:78023
Canis familiaris SPIRE2 VGNC VGNC:46749
Bos taurus SPIRE2 VGNC VGNC:35223
Rattus norvegicus SPIRE2 RGD RGD:1305837
Others SPIRE2 NCBI