2. Gene
  3. Topbp1 - topoisomerase (DNA) II binding protein 1 Gene

Topbp1 - topoisomerase (DNA) II binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA0259; 1110031N14Rik; 2810429C13Rik; D430026L04Rik

Gene ID: 235559 | Gene type: protein coding

About Topbp1

Summary

Predicted to enable identical protein binding activity. Predicted to be involved in DNA replication initiation; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to act upstream of or within reciprocal meiotic recombination. Located in condensed nuclear chromosome and male germ cell nucleus. Is expressed in embryo and metanephros. Orthologous to human TOPBP1 (DNA Topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Topbp1 Products(1)

mRNA Protein Name
NM_176979.5 NP_795953.2 DNA topoisomerase 2-binding protein 1
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in chromosome IDA
IDA: Inferred from direct assay
22549958 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
14718568 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
17696610 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA topoisomerase 2-binding protein 1

DNA topoisomerase II-beta-binding protein 1

DNA topoisomerase II-binding protein 1

topoisomerase (DNA) II beta binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160409 TopBP1-IN-1 98.35% Unkown
HY-RS14901 TOPBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Topbp1 NCBI NCBI:11073