Alms1 - ALMS1, centrosome and basal body associated Gene

Also Known as bbb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 236266

Summary

Enables alpha-actinin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including Cholesterol homeostasis; gamete generation; and neuron development. Predicted to be active in centriole; centrosome; and cytosol. Is expressed in several structures, including aorta; central nervous system; genitourinary system; gut; and sensory organ. Used to study Alstrom syndrome and obesity. Human ortholog(s) of this gene implicated in Alstrom syndrome. Orthologous to human ALMS1 (ALMS1 centrosome and basal body associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Alms1 Products (1)

mRNA Protein Name
NM_145223.2 NP_660258.2 centrosome-associated protein ALMS1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-actinin binding IPI
IPI: Inferred from physical interaction
22693585 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22693585 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
21071598 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16000322 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
21071598 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
16000322 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17206865 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16513793 MGI
acts upstream of or within ovulation IMP
IMP: Inferred from mutant phenotype
16513793 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27803297 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
16000322 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
31302159 MGI
acts upstream of or within retinal rod cell development IMP
IMP: Inferred from mutant phenotype
16000322 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
16000322 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
16513793 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosome-associated protein ALMS1

Alstrom syndrome protein 1 homolog

  • Alstrom syndrome 1 homolog

  • alstrom syndrome protein 1 homolog

Alms1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Alms1 Q8K4E0 Actn4 Mus musculus P57780
Y2H
22693585
Intra
Alms1 Q8K4E0 Actn4 Mus musculus P57780
Anti Bait CoIP
22693585
Intra
Alms1 Q8K4E0 Actn1 Mus musculus Q7TPR4
Y2H
22693585
Intra
Alms1 Q8K4E0 Exosc8 Mus musculus Q9D753
Y2H
22693585
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00611 ALMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22387 Alms1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28911 Alms1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alms1 NCBI NCBI:7840