Pla2g3 - phospholipase A2, group III Gene

Also Known as sPLA2-III

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237625

Summary

Enables calcium-dependent Phospholipase A2 activity. Involved in several processes, including positive regulation of histamine secretion by mast cell; positive regulation of mast cell differentiation; and positive regulation of prostaglandin biosynthetic process. Acts upstream of or within several processes, including negative regulation of amyloid-beta clearance; regulation of gene expression; and spermatid development. Predicted to be located in centriole and recycling endosome. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human PLA2G3 (Phospholipase A2 group III). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g3 Products (1)

mRNA Protein Name
NM_172791.2 NP_766379.2 group 3 secretory phospholipase A2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipase A2 activity IMP
IMP: Inferred from mutant phenotype
23624557 MGI
enables phospholipase activity IDA
IDA: Inferred from direct assay
28947740 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acrosome assembly IMP
IMP: Inferred from mutant phenotype
20424323 MGI
acts upstream of or within cell development IMP
IMP: Inferred from mutant phenotype
23624557 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
28947740 MGI
acts upstream of or within lipoxygenase pathway IMP
IMP: Inferred from mutant phenotype
20424323 MGI
acts upstream of or within macrophage activation IDA
IDA: Inferred from direct assay
28947740 MGI
acts upstream of or within mast cell degranulation IMP
IMP: Inferred from mutant phenotype
23624557 MGI
acts upstream of or within negative regulation of amyloid-beta clearance IDA
IDA: Inferred from direct assay
26637123 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
26637123 MGI
acts upstream of or within phosphatidylcholine metabolic process IMP
IMP: Inferred from mutant phenotype
20424323 MGI
acts upstream of or within phospholipid metabolic process IDA
IDA: Inferred from direct assay
28947740 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
28947740 MGI
involved in positive regulation of histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
23624557 MGI
involved in positive regulation of mast cell differentiation IMP
IMP: Inferred from mutant phenotype
23624557 MGI
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17868035 MGI
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
23624557 MGI
acts upstream of or within positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
28947740 MGI
acts upstream of or within production of molecular mediator involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
28947740 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
20424323 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

group 3 secretory phospholipase A2

  • GIII sPLA2

  • group III secretory phospholipase A2

  • phosphatidylcholine 2-acylhydrolase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10625 PLA2G3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g3 NCBI NCBI:50487