Pla2g3 - phospholipase A2, group III Gene

Mus musculus

Also known as sPLA2-III

Gene ID: 237625 | Gene type: protein coding

About Pla2g3

Summary

Enables calcium-dependent Phospholipase A2 activity. Involved in several processes, including positive regulation of histamine secretion by mast cell; positive regulation of mast cell differentiation; and positive regulation of prostaglandin biosynthetic process. Acts upstream of or within several processes, including negative regulation of amyloid-beta clearance; regulation of gene expression; and spermatid development. Predicted to be located in centriole and recycling endosome. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human PLA2G3 (Phospholipase A2 group III). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g3 Products(1)

mRNA	Protein	Name
NM_172791.2	NP_766379.2	group 3 secretory phospholipase A2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	23624557	MGI
enables phospholipase activity	IDA IDA: Inferred from direct assay	28947740	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acrosome assembly	IMP IMP: Inferred from mutant phenotype	20424323	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	23624557	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	28947740	MGI
acts upstream of or within lipoxygenase pathway	IMP IMP: Inferred from mutant phenotype	20424323	MGI
acts upstream of or within macrophage activation	IDA IDA: Inferred from direct assay	28947740	MGI
acts upstream of or within mast cell degranulation	IMP IMP: Inferred from mutant phenotype	23624557	MGI
acts upstream of or within negative regulation of amyloid-beta clearance	IDA IDA: Inferred from direct assay	26637123	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	26637123	MGI
acts upstream of or within phosphatidylcholine metabolic process	IMP IMP: Inferred from mutant phenotype	20424323	MGI
acts upstream of or within phospholipid metabolic process	IDA IDA: Inferred from direct assay	28947740	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28947740	MGI
involved in positive regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	23624557	MGI
involved in positive regulation of mast cell differentiation	IMP IMP: Inferred from mutant phenotype	23624557	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17868035	MGI
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	23624557	MGI
acts upstream of or within positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	28947740	MGI
acts upstream of or within production of molecular mediator involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28947740	MGI
acts upstream of or within sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	20424323	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

group 3 secretory phospholipase A2

GIII sPLA2	group III secretory phospholipase A2
phosphatidylcholine 2-acylhydrolase 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10625	PLA2G3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g3	NCBI	NCBI:50487

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