2. Gene
  3. PLA2G3 - phospholipase A2 group III Gene

PLA2G3 - phospholipase A2 group III Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPLA2III; sPLA2-III; GIII-SPLA2

Gene ID: 50487 | Gene type: protein coding

About PLA2G3

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,134,807-31,140,508 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues and 1 paralogue. Biased expression in skin (RPKM 3.5), esophagus (RPKM 1.9) and 4 other tissues.

Summary

This gene encodes a protein that belongs to the secreted Phospholipase A2 family, whose members include the bee venom Enzyme. The encoded Enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of Phospholipids to release arachidonic acid and lysophospholipids. This Enzyme acts as a negative regulator of ciliogenesis, and may play a role in Cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

PLA2G3 Products(1)

mRNA Protein Name
NM_015715.5 NP_056530.2 group 3 secretory phospholipase A2 precursor

PLA2G3 Protein Structure

Phospholip_A2_2

Phospholip_A2_2: Phospholipase A2 (152 - 250)

Phospholip_A2_2

Phospholip_A2_2: Phospholipase A2 (366 - 429)

  • 0
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  • 509 a.a.
Protein Preferred Names Protein Names

group 3 secretory phospholipase A2

group III secreted phospholipase A2

Related Diseases

Diseases Alias
Joubert Syndrome 23

JBTS23

Joubert Syndrome, Type 23
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10625 PLA2G3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G3 RGD RGD:1305323
Macaca mulatta PLA2G3 VGNC VGNC:107918
Felis catus PLA2G3 VGNC VGNC:64199
Canis familiaris PLA2G3 VGNC VGNC:44625
Mus musculus PLA2G3 MGD MGI:2444945
Bos taurus PLA2G3 VGNC VGNC:32959