Ttll6 - tubulin tyrosine ligase-like family, member 6 Gene

Also Known as t8130b59; D11Moh43e; D11Moh44e; 4932418K24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237930

Summary

Enables protein-glutamic acid Ligase activity and tubulin binding activity. Involved in protein polyglutamylation. Acts upstream of or within microtubule bundle formation; microtubule severing; and positive regulation of cilium movement. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; inner ear; and primitive streak. Orthologous to human TTLL6 (tubulin tyrosine Ligase like 6). [provided by Alliance of Genome Resources, Apr 2022]

Ttll6 Products (1)

mRNA Protein Name
NM_172799.4 NP_766387.2 tubulin polyglutamylase TTLL6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26829768 MGI
enables protein-glutamic acid ligase activity IDA
IDA: Inferred from direct assay
26829768 MGI
enables tubulin binding IDA
IDA: Inferred from direct assay
21074048 MGI
enables tubulin-glutamic acid ligase activity IDA
IDA: Inferred from direct assay
17499049 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within microtubule bundle formation IGI
IGI: Inferred from genetic interaction
20530212 MGI
acts upstream of or within microtubule severing IDA
IDA: Inferred from direct assay
20530212 MGI
acts upstream of or within microtubule severing IGI
IGI: Inferred from genetic interaction
20530212 MGI
acts upstream of or within positive regulation of cilium movement IMP
IMP: Inferred from mutant phenotype
23897886 MGI
acts upstream of or within protein polyglutamylation IDA
IDA: Inferred from direct assay
20530212 MGI
involved in protein polyglutamylation IDA
IDA: Inferred from direct assay
21074048 MGI
involved in regulation of cilium beat frequency involved in ciliary motility IDA
IDA: Inferred from direct assay
23897886 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+0 non-motile cilium IDA
IDA: Inferred from direct assay
17499049 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
17499049 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin polyglutamylase TTLL6

  • polyglutamylase

  • protein polyglutamylase TTLL6

  • tubulin--tyrosine ligase-like protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15233 TTLL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttll6 NCBI NCBI:284076