Ash2l - ASH2 like histone lysine methyltransferase complex subunit Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23808

Summary

Predicted to enable beta-catenin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to Histone Methyltransferase activity (H3-K4 specific). Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in euchromatin. Part of MLL1 complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut gland; and respiratory system. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ash2l Products (4)

mRNA Protein Name
NM_001080793.2 NP_001074262.1 set1/Ash2 histone methyltransferase complex subunit ASH2 isoform b
NM_001286207.1 NP_001273136.1 set1/Ash2 histone methyltransferase complex subunit ASH2 isoform b
NM_001359012.1 NP_001345941.1 set1/Ash2 histone methyltransferase complex subunit ASH2 isoform d
NM_011791.3 NP_035921.2 set1/Ash2 histone methyltransferase complex subunit ASH2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20463296 MGI
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
22723415 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

set1/Ash2 histone methyltransferase complex subunit ASH2

  • ASH2-like protein

  • ash2 (absent, small, or homeotic)-like

Ash2l Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ash2l Q91X20 Rbbp5 Mus musculus Q8BX09
GMS
21477851
Intra
Ash2l Q91X20 Rbbp5 Mus musculus Q8BX09
Ion Exchange Chrom
26320581
Intra
Ash2l Q91X20 Rbbp5 Mus musculus Q8BX09
Anti Bait CoIP
21448134
Intra
Ash2l Q91X20 Rbbp5 Mus musculus Q8BX09
GMS
26320581
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01088 ASH2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ash2l NCBI NCBI:9070