Ash2l - ASH2 like histone lysine methyltransferase complex subunit Gene

Mus musculus

Gene ID: 23808 | Gene type: protein coding

About Ash2l

Summary

Predicted to enable beta-catenin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to Histone Methyltransferase activity (H3-K4 specific). Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in euchromatin. Part of MLL1 complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut gland; and respiratory system. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ash2l Products(4)

mRNA	Protein	Name
NM_001080793.2	NP_001074262.1	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform b
NM_001286207.1	NP_001273136.1	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform b
NM_001359012.1	NP_001345941.1	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform d
NM_011791.3	NP_035921.2	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500065	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20463296	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	22723415	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

set1/Ash2 histone methyltransferase complex subunit ASH2

ASH2-like protein

ash2 (absent, small, or homeotic)-like

Ash2l Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ash2l	Q91X20	Rbbp5	Mus musculus	Q8BX09	GMS	21477851
Intra	Ash2l	Q91X20	Rbbp5	Mus musculus	Q8BX09	Ion Exchange Chrom	26320581
Intra	Ash2l	Q91X20	Rbbp5	Mus musculus	Q8BX09	Anti Bait CoIP	21448134
Intra	Ash2l	Q91X20	Rbbp5	Mus musculus	Q8BX09	GMS	26320581

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01088	ASH2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ash2l	NCBI	NCBI:9070

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