2. Gene
  3. Dlg2 - discs large MAGUK scaffold protein 2 Gene

Dlg2 - discs large MAGUK scaffold protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dlgh2; PSD93; Gm1197; Gm21505; A330103J02Rik; B230218P12Rik; B330007M19Rik

Gene ID: 23859 | Gene type: protein coding

About Dlg2

Summary

A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission and sensory perception of pain. Located in several cellular components, including main axon; postsynaptic density; and synaptic vesicle membrane. Is active in glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dlg2 Products(3)

mRNA Protein Name
NM_001243046.1 NP_001229975.1 disks large homolog 2 isoform 2
NM_001243047.1 NP_001229976.1 disks large homolog 2 isoform 3
NM_011807.3 NP_035937.2 disks large homolog 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16980967 MGI
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
17046693 MGI
enables structural constituent of postsynaptic density IEP
IEP: Inferred from expression pattern
17046693 MGI
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
17046693 MGI
Biological Process GO Annotation Evidence Reference Source
involved in anterograde axonal protein transport IGI
IGI: Inferred from genetic interaction
26609151 MGI
involved in cellular response to potassium ion IDA
IDA: Inferred from direct assay
26609151 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12890763 MGI
involved in clustering of voltage-gated potassium channels IDA
IDA: Inferred from direct assay
18509034 MGI
involved in clustering of voltage-gated potassium channels IMP
IMP: Inferred from mutant phenotype
18509034 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
17046693 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
IEP: Inferred from expression pattern
17046693 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
17046693 MGI
involved in retrograde axonal protein transport IGI
IGI: Inferred from genetic interaction
26609151 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12890763 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in axon initial segment IDA
IDA: Inferred from direct assay
18509034 MGI
is active in axon initial segment IMP
IMP: Inferred from mutant phenotype
18509034 MGI
located in cell junction IDA
IDA: Inferred from direct assay
21920314 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17046693 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17046693 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17046693 MGI
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
19109503 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
12890763 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29490264 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 2

channel-associated protein of synapse-110

chapsyn-110

discs large MAGUK scaffold protein 2 eta

discs large MAGUK scaffold protein 2 gamma

discs, large homolog 2

postsynaptic density protein PSD-93

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03797 DLG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08623 MPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19354 Mpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25845 Mpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg2 NCBI NCBI:1740