Dlg2 - discs large MAGUK scaffold protein 2 Gene

Also Known as Dlgh2; PSD93; Gm1197; Gm21505; A330103J02Rik; B230218P12Rik; B330007M19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23859

Summary

A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission and sensory perception of pain. Located in several cellular components, including main axon; postsynaptic density; and synaptic vesicle membrane. Is active in glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Dlg2 Products (3)

mRNA	Protein	Name
NM_001243046.1	NP_001229975.1	disks large homolog 2 isoform 2
NM_001243047.1	NP_001229976.1	disks large homolog 2 isoform 3
NM_011807.3	NP_035937.2	disks large homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16980967	MGI
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	17046693	MGI
enables structural constituent of postsynaptic density	IEP IEP: Inferred from expression pattern	17046693	MGI
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	17046693	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anterograde axonal protein transport	IGI IGI: Inferred from genetic interaction	26609151	MGI
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	26609151	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12890763	MGI
involved in clustering of voltage-gated potassium channels	IDA IDA: Inferred from direct assay	18509034	MGI
involved in clustering of voltage-gated potassium channels	IMP IMP: Inferred from mutant phenotype	18509034	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	17046693	MGI
involved in retrograde axonal protein transport	IGI IGI: Inferred from genetic interaction	26609151	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12890763	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in axon initial segment	IDA IDA: Inferred from direct assay	18509034	MGI
is active in axon initial segment	IMP IMP: Inferred from mutant phenotype	18509034	MGI
located in cell junction	IDA IDA: Inferred from direct assay	21920314	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17046693	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17046693	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17046693	MGI
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	19109503	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	12890763	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	29490264	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
disks large homolog 2	channel-associated protein of synapse-110 chapsyn-110 discs large MAGUK scaffold protein 2 eta discs large MAGUK scaffold protein 2 gamma discs, large homolog 2 postsynaptic density protein PSD-93

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03797	DLG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08623	MPP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19354	Mpp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25845	Mpp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg2	NCBI	NCBI:1740