Nlrp5 - NLR family, pyrin domain containing 5 Gene

Mus musculus

Also known as Op1; Mater; Nalp5; PAN11

Gene ID: 23968 | Gene type: protein coding

About Nlrp5

Summary

This gene encodes a member of the NACHT, leucine-rich repeat, and pyrin domain containing family. Members of this family have a pyrin domain at the N-terminus, a central NACHT domain, and a C-terminal leucine-rich repeat domain. This gene encodes a maternal-effect factor that is essential for early embryonic development in the mouse. Homozygous null mutant females are sterile, and embryos die following the first cleavage. This gene is required for endoplasmic reticulum redistribution and calcium homeostasis in oocytes. In addition, ovulated oocytes mutant for this gene have abnormal mitochondrial localization and increased mitochondrial activity, which results in mitochondrial damage and early embryonic lethality. Pseudogenes of this gene have been found on chromosomes 7 and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Nlrp5 Products(3)

mRNA	Protein	Name
NM_001039143.2	NP_001034232.1	NACHT, LRR and PYD domains-containing protein 5 isoform b
NM_001305857.1	NP_001292786.1	NACHT, LRR and PYD domains-containing protein 5 isoform c
NM_011860.3	NP_035990.1	NACHT, LRR and PYD domains-containing protein 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18057100	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	25208553	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10754103	MGI
involved in cortical granule exocytosis	IMP IMP: Inferred from mutant phenotype	31118423	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	18804437	MGI
involved in establishment of organelle localization	IMP IMP: Inferred from mutant phenotype	24374158	MGI
involved in establishment of spindle localization	IMP IMP: Inferred from mutant phenotype	25208553	MGI
involved in exocytosis	IMP IMP: Inferred from mutant phenotype	24374158	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	11062459	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	11062459	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	22357545	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	20830304	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	18804437	MGI
acts upstream of or within regulation of RNA stability	IMP IMP: Inferred from mutant phenotype	11062459	MGI
involved in regulation of cell division	IMP IMP: Inferred from mutant phenotype	25208553	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	22357545	MGI
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	18057100	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical cortex	IDA IDA: Inferred from direct assay	18057100	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	18057100	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20830304	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10433232	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	14670992	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	14670992	MGI
located in ooplasm	IDA IDA: Inferred from direct assay	18057100	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18057100	MGI
part of subcortical maternal complex	IDA IDA: Inferred from direct assay	18057100	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 5

NACHT, leucine rich repeat and PYD containing 5	maternal antigen that embryos require
ooplasm-specific protein 1

Nlrp5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nlrp5	Q9R1M5	Khdc3	Mus musculus	Q9CWU5	Anti Tag CoIP	18804437

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09361	NLRP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrp5	NCBI	NCBI:126206

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