Prkra - protein kinase, interferon inducible double stranded RNA dependent activator Gene

Also Known as PRK; RAX; Pact; lear

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23992

Summary

Predicted to enable RNA binding activity; protein homodimerization activity; and protein kinase binding activity. Acts upstream of or within several processes, including cellular response to oxidative stress; ear morphogenesis; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC-loading complex. Is expressed in several structures, including 4-cell stage embryo; central nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2). [provided by Alliance of Genome Resources, Apr 2022]

Prkra Products (1)

mRNA Protein Name
NM_011871.3 NP_036001.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452327 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to oxidative stress IDA
IDA: Inferred from direct assay
10336432 MGI
acts upstream of or within ear development IMP
IMP: Inferred from mutant phenotype
26234751 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
16571658 MGI
acts upstream of or within outer ear morphogenesis IMP
IMP: Inferred from mutant phenotype
16571658 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12181197 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
10336432 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
16571658 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16571658 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-inducible double-stranded RNA-dependent protein kinase activator A

  • PKR-associated protein X

  • PKR-associating protein X

  • protein activator of the interferon-induced protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0891 Tubeimoside II 99.90% Unkown
HY-RS11157 PRKRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkra NCBI NCBI:8575