Prkra - protein kinase, interferon inducible double stranded RNA dependent activator Gene

Mus musculus

Also known as PRK; RAX; Pact; lear

Gene ID: 23992 | Gene type: protein coding

About Prkra

Summary

Predicted to enable RNA binding activity; protein homodimerization activity; and protein kinase binding activity. Acts upstream of or within several processes, including cellular response to oxidative stress; ear morphogenesis; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC-loading complex. Is expressed in several structures, including 4-cell stage embryo; central nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2). [provided by Alliance of Genome Resources, Apr 2022]

Prkra Products(1)

mRNA	Protein	Name
NM_011871.3	NP_036001.1	interferon-inducible double-stranded RNA-dependent protein kinase activator A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452327	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to oxidative stress	IDA IDA: Inferred from direct assay	10336432	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	16571658	MGI
acts upstream of or within outer ear morphogenesis	IMP IMP: Inferred from mutant phenotype	16571658	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12181197	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	10336432	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	16571658	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	16571658	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon-inducible double-stranded RNA-dependent protein kinase activator A

PKR-associated protein X	PKR-associating protein X
protein activator of the interferon-induced protein kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0891	Tubeimoside II		99.90%	Unkown
HY-RS11157	PRKRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkra	NCBI	NCBI:8575

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