Peli3 - pellino 3 Gene

Also Known as A930011L17; 6030441F14Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 240518

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; protein K63-linked ubiquitination; and regulation of signal transduction. Is expressed in eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human PELI3 (pellino E3 ubiquitin protein Ligase family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Peli3 Products (2)

mRNA	Protein	Name
NM_001347422.1	NP_001334351.1	E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
NM_172835.3	NP_766423.3	E3 ubiquitin-protein ligase pellino homolog 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23042151	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23892723	MGI
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	23042151	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23892723	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	23892723	MGI
acts upstream of or within negative regulation of Toll signaling pathway	IGI IGI: Inferred from genetic interaction	23042151	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23950925	MGI
acts upstream of or within negative regulation of protein ubiquitination	IGI IGI: Inferred from genetic interaction	23042151	MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23950925	MGI
acts upstream of or within negative regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	23042151	MGI
acts upstream of or within positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	23892723	MGI
acts upstream of or within protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	23892723	MGI
acts upstream of or within regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP IMP: Inferred from mutant phenotype	23892723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase pellino homolog 3	RING-type E3 ubiquitin transferase pellino homolog 3 protein pellino homolog 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10322	PELI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Peli3	NCBI	NCBI:246330