PELI3 - pellino E3 ubiquitin protein ligase family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 246330

About PELI3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,466,327-66,477,337 (from NCBI)

This gene has 9 transcripts (splice variants), 179 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 6.1), ovary (RPKM 4.8) and 24 other tissues.

Summary

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PELI3 Products (4)

mRNA Protein Name
NM_001098510.2 NP_001091980.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
NM_001243135.2 NP_001230064.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 3
NM_001243136.2 NP_001230065.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform 4
NM_145065.3 NP_659502.2 E3 ubiquitin-protein ligase pellino homolog 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12874243 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
24113711 GOA
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24113711 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELI3 Protein Structure

Pellino

Pellino: Pellino (76 - 469)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase pellino homolog 3

  • RING-type E3 ubiquitin transferase pellino homolog 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10322 PELI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PELI3 RGD RGD:1305989
Felis catus PELI3 VGNC VGNC:81961
Bos taurus PELI3 VGNC VGNC:32742
Macaca mulatta PELI3 VGNC VGNC:75886
Mus musculus PELI3 MGD MGI:1924963
Canis familiaris PELI3 VGNC VGNC:44416