Carf - calcium response factor Gene

Mus musculus

Also known as Als2cr8; ECBRC-FC1; ECBRC-FC2

Gene ID: 241066 | Gene type: protein coding

About Carf

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-binding transcription factor activity. Located in granular component. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and skeletal muscle tissue. Orthologous to human CARF (calcium responsive transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Carf Products(3)

mRNA	Protein	Name
NM_001285463.1	NP_001272392.1	calcium-responsive transcription factor isoform 2
NM_001285473.1	NP_001272402.1	calcium-responsive transcription factor isoform 3
NM_139150.5	NP_631889.1	calcium-responsive transcription factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11832226	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11832226	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11832226	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12154087	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11832226	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11832226	MGI
acts upstream of or within regulation of DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	12154087	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in granular component	IDA IDA: Inferred from direct assay	12154087	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11832226	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcium-responsive transcription factor

amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog

calcium-response factor CaRF

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01924	CARF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Carf	NCBI	NCBI:79800

Name
Email *

	Sorry, but the email address you supplied was invalid.