CARF - calcium responsive transcription factor Gene

Homo sapiens

Also known as ALS2CR8; NYD-SP24

Gene ID: 79800 | Gene type: protein coding

About CARF

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:202,912,275-202,988,263 (from NCBI)

This gene has 20 transcripts (splice variants) and 172 orthologues. Broad expression in testis (RPKM 5.9), thyroid (RPKM 3.4) and 24 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in cellular response to potassium ion and positive regulation of transcription from RNA polymerase II promoter in response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CARF Products(12)

mRNA	Protein	Name
NM_001104586.4	NP_001098056.1	calcium-responsive transcription factor isoform 1
NM_001282910.3	NP_001269839.1	calcium-responsive transcription factor isoform 2
NM_001282911.3	NP_001269840.1	calcium-responsive transcription factor isoform 2
NM_001282912.3	NP_001269841.1	calcium-responsive transcription factor isoform 3
NM_001322427.3	NP_001309356.1	calcium-responsive transcription factor isoform 1
NM_001322428.3	NP_001309357.1	calcium-responsive transcription factor isoform 1
NM_001322429.3	NP_001309358.1	calcium-responsive transcription factor isoform 4
NM_001352676.2	NP_001339605.1	calcium-responsive transcription factor isoform 6
NM_001352677.2	NP_001339606.1	calcium-responsive transcription factor isoform 7
NM_001352678.2	NP_001339607.1	calcium-responsive transcription factor isoform 8
NM_001352679.2	NP_001339608.1	calcium-responsive transcription factor isoform 8
NM_024744.17	NP_079020.13	calcium-responsive transcription factor isoform 1

CARF Protein Structure

ALS2CR8

0
200
400
600
725 a.a.

Protein Preferred Names

Protein Names

calcium-responsive transcription factor

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 2, Juvenile

ALS2	Als, Juvenile
Alsj	Amyotrophic Lateral Sclerosis Type 2
Amyotrophic Lateral Sclerosis 2	Amyotrophic Lateral Sclerosis Type 2, Juvenile
Amyotrophic Lateral Sclerosis Juvenile	Amyotrophic Lateral Sclerosis Juvenile 2
Sclerosis, Lateral, Amyotrophic, Type Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01924	CARF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CARF	VGNC	VGNC:38719
Mus musculus	CARF	MGD	MGI:2182269
Macaca mulatta	CARF	VGNC	VGNC:70518
Felis catus	CARF	VGNC	VGNC:107493
Rattus norvegicus	CARF	RGD	RGD:1306822
Bos taurus	CARF	VGNC	VGNC:26765