Padi6 - peptidyl arginine deiminase, type VI Gene

Mus musculus

Also known as P75; Pad6; ePAD; Padi5

Gene ID: 242726 | Gene type: protein coding

About Padi6

Summary

Enables protein-arginine deiminase activity. Involved in embryonic cleavage. Acts upstream of or within cellular protein metabolic process; cytoplasm organization; and Cytoskeleton organization. Located in cortical granule and intermediate filament Cytoskeleton. Is expressed in 2-cell stage embryo; ileum; and reproductive system. Human ortholog(s) of this gene implicated in infertility. Orthologous to human PADI6 (peptidyl arginine deiminase 6). [provided by Alliance of Genome Resources, Apr 2022]

Padi6 Products(1)

mRNA	Protein	Name
NM_153106.2	NP_694746.2	protein-arginine deiminase type-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18463355	MGI
enables protein-arginine deiminase activity	IMP IMP: Inferred from mutant phenotype	17587491	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytoplasm organization	IMP IMP: Inferred from mutant phenotype	18599511	MGI
acts upstream of or within cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17587491	MGI
involved in embryonic cleavage	IDA IDA: Inferred from direct assay	16137333	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	18599511	MGI
acts upstream of or within regulation of translation by machinery localization	IMP IMP: Inferred from mutant phenotype	18599511	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cortical granule	IDA IDA: Inferred from direct assay	16137333	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12654293	MGI
located in intermediate filament cytoskeleton	IDA IDA: Inferred from direct assay	12654293	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein-arginine deiminase type-6

arginine deiminase-like protein	egg and embryo abundant PAD
peptidyl arginine deiminase, egg and embryo abundant	peptidylarginine deiminase VI
protein-arginine deiminase type VI

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09964	PADI6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Padi6	NCBI	NCBI:353238

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