PADI6 - peptidyl arginine deiminase 6 Gene

Also Known as hPADVI; PREMBL2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 353238

About PADI6

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,372,196-17,401,699 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 240 orthologues, 4 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

PADI6 Products (1)

mRNA	Protein	Name
NM_207421.4	NP_997304.3	protein-arginine deiminase type-6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27545678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein-arginine deiminase type-6	peptidyl arginine deiminase, type VI

PADI6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PADI6	Q6TGC4	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
Intra	PADI6	Q6TGC4	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	PADI6	Q6TGC4	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	PADI6	Q6TGC4	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	PADI6	Q6TGC4	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	PADI6	Q6TGC4	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	PADI6	Q6TGC4	KLHL2	Homo sapiens	O95198	Y2H Array	32296183
Intra	PADI6	Q6TGC4	KLHL2	Homo sapiens	O95198	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Preimplantation Embryonic Lethality 2	PREMBL2 Lethality, Embryonic, Preimplantation, Type 2
Infertility
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09964	PADI6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PADI6	VGNC	VGNC:32549
Rattus norvegicus	PADI6	RGD	RGD:1560424
Macaca mulatta	PADI6	VGNC	VGNC:75657
Felis catus	PADI6	VGNC	VGNC:64023
Mus musculus	PADI6	MGD	MGI:2655198
Canis familiaris	PADI6	VGNC	VGNC:44238
Others	PADI6	NCBI