Gapdh - glyceraldehyde-3-phosphate dehydrogenase Gene

Also Known as Gapd; BARS-38

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24383

Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies in human and mouse have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins. Many pseudogenes similar to this locus are found throughout the rat genome. [provided by RefSeq, Jan 2014]

Gapdh Products (1)

mRNA Protein Name
NM_017008.4 NP_058704.1 glyceraldehyde-3-phosphate dehydrogenase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
IDA: Inferred from direct assay
15720133 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
27129213 RGD
enables microtubule binding IDA
IDA: Inferred from direct assay
15312048 RGD
enables peptidyl-cysteine S-nitrosylase activity IDA
IDA: Inferred from direct assay
20972425 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15312048 RGD
Biological Process GO Annotation Evidence References Source
involved in cAMP/PKA signal transduction IMP
IMP: Inferred from mutant phenotype
28258188 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
27312951 RGD
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
15720133 RGD
involved in gluconeogenesis IMP
IMP: Inferred from mutant phenotype
28258188 RGD
involved in glycolytic process IMP
IMP: Inferred from mutant phenotype
28258188 RGD
involved in microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
15312048 RGD
involved in negative regulation of vascular associated smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
28404743 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15951807 RGD
involved in nitric oxide mediated signal transduction IDA
IDA: Inferred from direct assay
19607794 RGD
involved in peptidyl-cysteine S-trans-nitrosylation IDA
IDA: Inferred from direct assay
20972425 RGD
involved in protein stabilization IDA
IDA: Inferred from direct assay
15951807 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15312048 RGD
located in cytosol IDA
IDA: Inferred from direct assay
15951807 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9371836 RGD
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15312048 RGD
located in nucleus IDA
IDA: Inferred from direct assay
15951807 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
9371836 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glyceraldehyde-3-phosphate dehydrogenase

  • 38 kDa BFA-dependent ADP-ribosylation substrate

  • peptidyl-cysteine S-nitrosylase GAPDH

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1087 Prednisolone hemisuccinate 99.89% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16361A Omigapil maleate Inhibitor 99.84% Phase 2
HY-16361 Omigapil Inducer / Phase 2
HY-147280 Misetionamide Inducer 99.49% Phase 1

Pre-clinical Phase

Bioactive Molecules (102)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0849 Sodium iodoacetate Inhibitor 99.91% Unkown
HY-123962 G6PD activator AG1 99.54% Unkown
HY-112758 DLin-KC2-DMA 99.88% Unkown
HY-P2804 GAPDH, rabbit muscle 96.00% Unkown
HY-120838 Heptelidic acid Inhibitor 97.5% Unkown
HY-157395 malonyl-NAC Inhibitor 98.74% Unkown
HY-43643 DC-5163 Inducer 99.30% Unkown
HY-N15156 Thiotaurine 99.27% Unkown
HY-156823 GAPDH Positive Control siRNA (Human) Pre-designed Set 98.72% Unkown
HY-156824 GAPDH siRNA Positive Control (Mouse/Rat) Pre-designed Set 98.09% Unkown
HY-171036 GAPDH-IN-1 Inhibitor 98.10% Unkown
HY-RS29497 GAL3ST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-RS29457 TMEM175 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00759 ANXA11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00845 APOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05274 GAPDHS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128788A ddhCTP trisodium solution (100 mM) Inhibitor / Unkown
HY-RS00844 APOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16258 Lipt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16283 FAM-labeled P3H3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29445 Ndufaf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29463 GCNT4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29469 GPR146 Domestic cattle Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29474 Dpm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29475 CEPT1 Human/Cat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29476 Akap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29477 Mmachc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29478 Vps13b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29483 GM2A Cattle Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29484 Tnxb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29490 Zpbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29491 Taco1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29492 Itpr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29496 Prkaa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29498 LOC771 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29499 SP1 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29507 Hnrnpdl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29509 Rab7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29510 Ociad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29512 AP1AR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29515 Slc30a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29516 BLOC1S3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29518 Rab7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29519 C1ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119062 A-800141 Inhibitor / Unkown
HY-123668 KM05382 Inhibitor / Unkown
HY-128788 ddhCTP Inhibitor / Unkown
HY-131921 DL-Glyceraldehyde 3-phosphate diethyl acetal barium / Unkown
HY-161668 Ru-Poma / Unkown
HY-184150 EN10 Ligand / Unkown
HY-186183 Normethyl-ZCAN262 Modulator / Unkown
HY-N3247 Monomethyl kolavate Inhibitor / Unkown
HY-RS01637 BRSK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01840 CALM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01842 CALM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02352 CDK11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04221 EHD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05787 GRHL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05789 GRHL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06491 HUNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10438 PHKA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15382 UBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29504 Acot4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170714 siRNA positive control (Rat GAPDH) (2-OMe) Pre-designed Set / Unkown
HY-RS16268 Islr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16274 Human CDC27P10 Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16289 St6galnac4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16311 Herc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17563 Anxa10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18382 Cdk10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19408 Apoa4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19983 Apoa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22883 Trrap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23297 Hipk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23792 Brsk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24288 Trio Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24540 Fosl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24560 Anxa13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24635 Anxa6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25291 Anxa4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25348 Cnksr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25659 Anxa8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26152 Calm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26883 Cdk15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27368 Anxa9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27463 Grhl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29448 ILF2 Pig Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29449 ANKRD31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29456 Ncr3lg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29458 Tmem19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29459 Tmem19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29468 Spaca1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29486 SLC25A15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29489 Eqtn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29493 Efr3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29495 Glis3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29505 Dnajc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29506 ZNF22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29508 Myo19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29511 Serpina1a Mouse Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gapdh NCBI NCBI:2597
Mus musculus Gapdh NCBI NCBI:14433